Benefits of exercise intervention in reducing neuropathic pain.
Benefits of exercise intervention in reducing neuropathic pain.
复制标题
DOI：
10.3389/fncel.2014.00102
复制
发表时间：
2014
影响因子：
5.3
通讯作者：
Li L
中科院分区：
文献类型：
--
作者：
Dobson JL;McMillan J;Li L
周围神经病是一种广泛存在的、具有潜在致残性的病理疾病，包括100多种不同形式和表现的神经损害。周围神经病的发病机制多种多样，影响自主神经、运动神经元和/或感觉神经元，其典型症状是皮肤感觉异常、肌肉功能障碍，最显著的是慢性疼痛。慢性神经性疼痛很难治疗，通常的特征是对疼痛刺激的过度反应(痛觉过敏)或由通常不会引起疼痛的刺激引起的疼痛(超感痛感)。这篇综述的目的是提供与周围神经病变发展相关的一些途径的概述，然后讨论运动干预的好处。神经病理性疼痛的发展是一个高度复杂和多因素的过程，但最近的证据表明，通过糖原合成酶激酶3激活脊髓神经胶质细胞以及增加促炎细胞因子和脑源性神经营养因子的产生是至关重要的步骤。由于许多最常见的周围神经病原因无法完全治疗，因此了解常规运动不仅有助于预防其中一些原因，而且它也已被证明是缓解这种疾病一些最令人痛苦的症状的有效手段，这一点至关重要。需要更多的研究来阐明与周围神经病变相关的典型损伤机制以及运动对这些机制的好处。
Peripheral neuropathy is a widespread and potentially incapacitating pathological condition that encompasses more than 100 different forms and manifestations of nerve damage. The diverse pathogenesis of peripheral neuropathy affects autonomic, motor and/or sensory neurons, and the symptoms that typify the condition are abnormal cutaneous sensation, muscle dysfunction and, most notably, chronic pain. Chronic neuropathic pain is difficult to treat and is often characterized by either exaggerated responses to painful stimuli (hyperalgesia) or pain resulting from stimuli that would not normally provoke pain (allodynia). The objective of this review is to provide an overview of some pathways associated with the development of peripheral neuropathy and then discuss the benefits of exercise interventions. The development of neuropathic pain is a highly complex and multifactorial process, but recent evidence indicates that the activation of spinal glial cells via the enzyme glycogen synthase kinase 3 and increases in the production of both pro-inflammatory cytokines and brain derived neurotropic factor are crucial steps. Since many of the most common causes of peripheral neuropathy cannot be fully treated, it is critical to understand that routine exercise may not only help prevent some of those causes, but that it has also proven to be an effective means of alleviating some of the condition’s most distressing symptoms. More research is required to elucidate the typical mechanisms of injury associated with peripheral neuropathy and the exercise-induced benefits to those mechanisms.
登录
查看更多内容
影响因子：
3.1
作者：
Bernardi C;Tramontina AC;Nardin P;Biasibetti R;Costa AP;Vizueti AF;Batassini C;Tortorelli LS;Wartchow KM;Dutra MF;Bobermin L;Sesterheim P;Quincozes-Santos A;de Souza J;Gonçalves CA
通讯作者：
Gonçalves CA
影响因子：
3.3
作者：
Bobinski, F.;Martins, D. F.;Santos, A. R. S.
通讯作者：
Santos, A. R. S.
影响因子：
14.5
作者：
Andreassen, C. S.;Jakobsen, J.;Andersen, H.
通讯作者：
Andersen, H.
DOI：
10.1073/pnas.0409225102
发表时间：
2005-02-01
影响因子：
11.1
作者：
Cunha, TM;Verri, WA;Ferreira, SH
通讯作者：
Ferreira, SH
影响因子：
3
作者：
Balducci, Stefano;Iacobellis, Gianluca;Fallucca, Francesco
通讯作者：
Fallucca, Francesco