Lactobacillus plantarum attenuates anxiety-related behavior and protects against stress-induced dysbiosis in adult zebrafish.
Lactobacillus plantarum attenuates anxiety-related behavior and protects against stress-induced dysbiosis in adult zebrafish.
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DOI：
10.1038/srep33726
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发表时间：
2016-09-19
影响因子：
4.6
通讯作者：
Bryda EC
中科院分区：
文献类型：
--
作者：
Davis DJ;Doerr HM;Grzelak AK;Busi SB;Jasarevic E;Ericsson AC;Bryda EC
益生菌的消费已成为越来越受欢迎的一种手段，试图改善健康和福祉。益生菌不仅被认为有益于消化系统健康，而且越来越多的证据表明肠道微生物群（GM）和中枢神经系统（CNS）之间存在直接和间接的相互作用。在这里，成年斑马鱼补充了植物乳杆菌，以确定益生菌治疗对GM结构和功能变化以及宿主神经和行为变化的影响。L. plantarum给药改变了GM的β-多样性，同时保持主要核心结构完整。这些微小的结构变化伴随着几种预测的代谢途径的显著富集。除了转基因改造外，L.植物药治疗还显著降低了焦虑相关行为，并改变了大脑中的GABA能和多巴胺能信号传导。最后，L。plantarum补充剂提供了针对压力诱导的转基因生态失调的保护。这些结果强调了转基因微生物对宿主生理功能的影响，并证明了转基因与宿主之间的双向交流。
The consumption of probiotics has become increasingly popular as a means to try to improve health and well-being. Not only are probiotics considered beneficial to digestive health, but increasing evidence suggests direct and indirect interactions between gut microbiota (GM) and the central nervous system (CNS). Here, adult zebrafish were supplemented with Lactobacillus plantarum to determine the effects of probiotic treatment on structural and functional changes of the GM, as well as host neurological and behavioral changes. L. plantarum administration altered the β-diversity of the GM while leaving the major core architecture intact. These minor structural changes were accompanied by significant enrichment of several predicted metabolic pathways. In addition to GM modifications, L. plantarum treatment also significantly reduced anxiety-related behavior and altered GABAergic and serotonergic signaling in the brain. Lastly, L. plantarum supplementation provided protection against stress-induced dysbiosis of the GM. These results underscore the influence commensal microbes have on physiological function in the host, and demonstrate bidirectional communication between the GM and the host.
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影响因子：
2.7
作者：
Egan, Rupert J.;Bergner, Carisa L.;Hart, Peter C.;Cachat, Jonathan M.;Canavello, Peter R.;Elegante, Marco F.;Elkhayat, Salem I.;Bartels, Brett K.;Tien, Anna K.;Tien, David H.;Mohnot, Sopan;Beeson, Esther;Glasgow, Eric;Amri, Hakima;Zukowska, Zofia;Kalueff, Allan V.
通讯作者：
Kalueff, Allan V.
影响因子：
3.7
作者：
Hart ML;Meyer A;Johnson PJ;Ericsson AC
通讯作者：
Ericsson AC
影响因子：
4.6
作者：
Falcinelli S;Picchietti S;Rodiles A;Cossignani L;Merrifield DL;Taddei AR;Maradonna F;Olivotto I;Gioacchini G;Carnevali O
通讯作者：
Carnevali O
影响因子：
3.7
作者：
Chakravarty S;Reddy BR;Sudhakar SR;Saxena S;Das T;Meghah V;Brahmendra Swamy CV;Kumar A;Idris MM
通讯作者：
Idris MM
影响因子：
4.2
作者：
Hemarajata, Peera;Versalovic, James
通讯作者：
Versalovic, James