Of flies, mice and neural control of food intake: lessons to learn from both models.

Of flies, mice and neural control of food intake: lessons to learn from both models.
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DOI:
10.1016/j.conb.2022.102531
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发表时间:
2022-04
影响因子:
5.7
通讯作者:
--
中科院分区:
医学2区
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--
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著名作家弗吉尼亚·伍尔夫在她的《一间自己的房间》一书中写道:“如果一个人没有好好吃饭,他就不能好好思考,好好爱,好好睡。”这倒是真的。所有的动物都需要觅食和消耗特定的营养物质来维持它们的生理稳态,最大限度地提高它们的健康和繁殖。经过几十年对人类和许多模式生物的研究,我们现在知道我们的大脑是控制我们吃什么、什么时候吃、吃多少的关键角色之一。在这篇综述中,我们讨论了最近的文献在小鼠和苍蝇的食物摄入行为的神经控制,认为这两个模式生物相互补充,努力揭示保守的原则,大脑用来调节能量代谢和食物摄入。
In her book, A Room of One’s Own, the famous author Virginia Woolf writes “One cannot think well, love well, sleep well if one has not dined well”. This is true. All animals need to forage for food and consume specific nutrients to maintain their physiological homeostasis, maximize their fitness and reproduction. After decades of research in humans and many model organisms, we now know that our brain is one of the key players that control what, when, and how much we eat. In this review, we discuss the recent literature on neural control of food intake behaviors in mice and flies with the view that the two model organisms complement one another in efforts to uncover conserved principles brains use to regulate energy metabolism and food ingestion.
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