Associations of amylin with inflammatory markers and metabolic syndrome in apparently healthy Chinese.
Associations of amylin with inflammatory markers and metabolic syndrome in apparently healthy Chinese.
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胰淀素与表面健康的中国人炎症标志物和代谢综合征的关联
DOI：
10.1371/journal.pone.0024815
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
Le Y
中科院分区：
文献类型：
--
作者：
Hou X;Sun L;Li Z;Mou H;Yu Z;Li H;Jiang P;Yu D;Wu H;Ye X;Lin X;Le Y
背景细胞和动物研究暗示胰淀素在调节胰岛素作用、葡萄糖和脂质代谢中的多种作用。然而，胰淀素在肥胖相关的代谢紊乱中的作用尚未在人类中彻底研究。因此，我们的目的是评估循环胰淀素的分布及其与代谢综合征（MetS）的关联，并探讨这种关联是否受到肥胖，炎症标志物或胰岛素抵抗的影响。方法对1,011名35-54岁的中国男性和女性进行血浆胰淀素、炎症标志物（C-反应蛋白[CRP]和白细胞介素-6 [IL-6]）、胰岛素、血糖和血脂水平测定。MetS是根据更新的美国国家胆固醇教育计划成人治疗组III亚裔美国人标准定义的。结果超重/肥胖组血浆胰淀素浓度高于正常体重组（P<0.001），无性别差异。循环胰淀素与CRP、IL-6、BMI、腰围、血压、空腹血糖、胰岛素、胰淀素/胰岛素比值、HOMA-IR、LDL胆固醇和甘油三酯呈正相关，与HDL胆固醇呈负相关（均P<0.001）。多重校正后，与最高和最低胰淀素四分位数相比，MetS的风险显著更高（比值比3.71; 95%置信区间：2.53至5.46）。该协会仍然显着，甚至进一步控制BMI，炎症标志物，胰岛素或HOMA-IR. Conclusions我们的研究表明，胰淀素与炎症标志物和代谢综合征密切相关。胰淀素-代谢综合征的关联是独立的代谢综合征的既定危险因素，包括肥胖，炎症标志物和胰岛素抵抗。高淀粉酶血症在代谢综合征发生中的因果作用需要进一步证实。
Background Cellular and animal studies implicate multiple roles of amylin in regulating insulin action, glucose and lipid metabolisms. However, the role of amylin in obesity related metabolic disorders has not been thoroughly investigated in humans. Therefore, we aimed to evaluate the distribution of circulating amylin and its association with metabolic syndrome (MetS) and explore if this association is influenced by obesity, inflammatory markers or insulin resistance in apparently healthy Chinese. Methods A population-based sample of 1,011 Chinese men and women aged 35–54 years was employed to measure plasma amylin, inflammatory markers (C-reactive protein [CRP] and interleukin-6 [IL-6]), insulin, glucose and lipid profiles. MetS was defined according to the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian-Americans. Results Plasma amylin concentrations were higher in overweight/obese participants than normal-weight counterparts (P<0.001) without sex difference. Circulating amylin was positively associated with CRP, IL-6, BMI, waist circumference, blood pressure, fasting glucose, insulin, amylin/insulin ratio, HOMA-IR, LDL cholesterol and triglycerides, while negatively associated with HDL cholesterol (all P<0.001). After multiple adjustments, the risk of MetS was significantly higher (odds ratio 3.71; 95% confidence interval: 2.53 to 5.46) comparing the highest with the lowest amylin quartile. The association remained significant even further controlling for BMI, inflammatory markers, insulin or HOMA-IR. Conclusions Our study suggests that amylin is strongly associated with inflammatory markers and MetS. The amylin-MetS association is independent of established risk factors of MetS, including obesity, inflammatory markers and insulin resistance. The causal role of hyperamylinemia in the development of MetS needs to be confirmed prospectively.
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