Shifts in discriminative control with increasing periods of recovery in the rat.
Shifts in discriminative control with increasing periods of recovery in the rat.
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DOI：
10.1111/acer.12048
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发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
Lamb RJ
中科院分区：
文献类型：
--
作者：
Ginsburg BC;Lamb RJ
在从酗酒中恢复的过程中，其他行为可能会增加。另类行为的发展可能会减少对酒精相关刺激的注意。当个体再次遇到与酒精相关的刺激时，这可能导致更持久的替代行为，这可能导致复发。建立这一过程的动物模型有助于更好地理解复发和恢复的机制。然而，目前的临床前康复和复发模型很少测量替代行为。因此，我们的目标是在大鼠中建立一个程序，其中替代行为（对食物的反应）的增加减少了对乙醇的反应。在改变对食物的反应增加和对乙醇的反应减少的次数后，再次暴露于酒精相关刺激后，对食物和乙醇的反应量进行评估。这些结果与平行组对糖精溶液而不是乙醇的反应进行了比较。溶液（乙醇或糖精）在5种反应下均可获得。闪烁的刺激灯表明食物递送跟随150个反应，并导致对溶液的主要反应（占总反应的84 - 86%）。固体刺激灯的呈现表明，食物递送遵循5种反应，并导致对食物的反应主要（总反应的1 - 3%是对溶液的反应）。大鼠连续暴露在固体光条件下0、1、2、4或16次，然后再次暴露在闪烁的刺激光中。当大鼠再次暴露于闪烁的刺激灯（与溶液优势反应有关）时，对任何一种溶液的反应都恢复了。然而，更多的反应发生在食物杠杆上，并且最近对食物而不是解决方案做出反应的历史更长。这些结果表明，替代行为取代饮酒的时间越长，对与饮酒相关的刺激的关注就越少。这些结果与这样一种观点是一致的，即随着恢复时间的延长，复发的风险会下降，因为即使在与饮酒相关的刺激存在的情况下，替代行为也会占主导地位。
During recovery from alcoholism, other behavior likely increases. The development of alternative behavior may reduce attention to alcohol-associated stimuli. This could result in greater persistence of the alternative behavior when individuals again encounter alcohol-associated stimuli that might precipitate relapse. Developing animal models of this process could facilitate a better understanding of the mechanisms involved in relapse and recovery. However, current pre-clinical models of recovery and relapse rarely measure alternative behavior. Thus, our objective was to establish a procedure in rats in which an increase in alternative behavior (responding for food) reduced responding for ethanol. The amount of responding for food and ethanol was then assessed after re-exposure to the alcohol-associated stimulus after varying the number of preceding sessions of increased responding for food and reduced responding for ethanol. These results were compared with those from a parallel group responding for saccharin solution instead of ethanol. The solution (ethanol or saccharin) was always available following 5 responses. Presentation of flashing stimulus lights indicated food delivery followed 150 responses and resulted in responding predominately for the solution (84 – 86% of total responses). Presentation of solid stimulus lights indicated food delivery followed 5 responses and resulted in responding predominately for food (1 – 3% of total responses were for the solution). Rats were exposed to solid light conditions for 0, 1, 2, 4, or 16 consecutive sessions before being re-exposed to the flashing stimulus lights in extinction. Responding for either solution resumed when rats were re-exposed to the flashing stimulus lights (associated with solution-predominate responding). However, more responses occurred on the food lever with longer recent histories of responding for food instead of the solution. These results suggest that the longer alternative behavior replaces drinking, the more that attention to stimuli associated with drinking decreases. These results are consistent with the notion that the risk of relapse declines with longer periods of recovery because alternative behavior comes to predominate even in the presence of stimuli associated with drinking.
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影响因子：
3.4
作者：
Cox, W. Miles;Pothos, Emmanuel M.;Hosier, Steven G.
通讯作者：
Hosier, Steven G.
影响因子：
2.9
作者：
Athens, Elizabeth S.;Vollmer, Timothy R.
通讯作者：
Vollmer, Timothy R.
影响因子：
3.4
作者：
Townshend, JM;Duka, T
通讯作者：
Duka, T
DOI：
10.1097/chi.0b013e3181825ace
发表时间：
2008-10
影响因子：
13.3
作者：
Roy AK;Vasa RA;Bruck M;Mogg K;Bradley BP;Sweeney M;Bergman RL;McClure-Tone EB;Pine DS;CAMS Team
通讯作者：
CAMS Team
影响因子：
12.8
作者：
Dobson, KS;Dozois, DJA
通讯作者：
Dozois, DJA