The melanin-concentrating hormone (MCH) system in an animal model of depression-like behavior.
The melanin-concentrating hormone (MCH) system in an animal model of depression-like behavior.
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DOI：
10.1016/j.euroneuro.2011.12.001
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发表时间：
2012-08
影响因子：
5.6
通讯作者：
Civelli, O.
中科院分区：
文献类型：
--
作者：
Garcia-Fuster, M. J.;Parks, G. S.;Clinton, S. M.;Watson, S. J.;Akil, H.;Civelli, O.
Selective breeding for divergence in locomotion in a novel environment (bHR, bred High-Responder; bLR, bred Low-Responder) correlates with stress-reactivity, spontaneous anxiety-like behaviors and predicts vulnerability in a rodent model of depression. Identifying genetic factors that may account for such vulnerability are key determinants not only for the illness outcome but also for the development of better-tailored treatment options. Melanin-concentrating hormone (MCH) is a neuropeptide that exhibits some of the hallmarks of a regulator of affective states. The aim of this study was to ascertain the role of the MCH system in depression-like behaviors in bHR vs. bLR rats. bLR rats showed a 44% increase in hypothalamic pMCH mRNA and a 14% decrease in hippocampal CA1 MCH1R mRNA when compared to bHR rats. Interestingly, the amount of time that rats spent immobile in the FST (depressive-like behavior) correlated positively with the amount of hypothalamic pMCH mRNA and negatively with that of hippocampal CA1 MCH1R. The results indicate that the bLR-bHR is a useful rat model to investigate individual basal genetic differences that participate in the monitoring of emotional responsiveness (i.e., depression- and anxiety-like behaviors). They also point to the MCH system (i.e., chronically higher pMCH expression and consequently receptor down-regulation) as a candidate biomarker for the severity of depressive-like behavior. The data indicate that MCH1R participates in the modulation of depression-like behavior through a process that involves the CA1 region of the hippocampus, supporting the possible use of MCH1R antagonists in the treatment of depression.
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影响因子：
3.5
作者：
Clinton, Sarah M.;Bedrosian, Tracy A.;Abraham, Antony D.;Watson, Stanley J.;Akil, Huda
通讯作者：
Akil, Huda
影响因子：
2.5
作者：
Kerman, Ilan A.;Bernard, Rene;Watson, Stanley J.
通讯作者：
Watson, Stanley J.
DOI：
10.1124/jpet.104.081711
发表时间：
2005-05-01
影响因子：
3.5
作者：
Chaki, S;Funakoshi, T;Thomsen, W
通讯作者：
Thomsen, W
DOI：
10.1124/jpet.108.143362
发表时间：
2009-05-01
影响因子：
3.5
作者：
Gehlert, Donald R.;Rasmussen, Kurt;Witkin, Jeffrey M.
通讯作者：
Witkin, Jeffrey M.
影响因子：
3.7
作者：
Clinton, Sarah;Miller, Sue;Akil, Huda
通讯作者：
Akil, Huda