Brain structure and cognitive correlates of body mass index in healthy older adults.
Brain structure and cognitive correlates of body mass index in healthy older adults.
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DOI：
10.1016/j.bbr.2014.10.010
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发表时间：
2015-02-01
影响因子：
2.7
通讯作者：
Paul, Robert H.
中科院分区：
文献类型：
--
作者：
Bolzenius, Jacob D.;Laidlaw, David H.;Cabeen, Ryan P.;Conturo, Thomas E.;McMichael, Amanda R.;Lane, Elizabeth M.;Heaps, Jodi M.;Salminen, Lauren E.;Baker, Laurie M.;Scott, Staci E.;Cooley, Sarah A.;Gunstad, John;Paul, Robert H.
肥胖，通常用体重指数（BMI）来衡量，与许多有害的健康状况有关，包括与高龄有关的大脑完整性的改变。先前的研究表明，使用扩散张量成像（DTI）观察到的白色物质的完整性与高BMI有关，但对特定白色物质束的完整性仍知之甚少。此外，没有研究检查白色物质束的完整性与神经心理学评估与老年人的BMI。本研究使用DTI检查了62名年龄在51至81岁的健康老年人（20名男性，42名女性）的白色束完整性和与BMI相关的认知表现。结果显示，BMI升高与钩束各向异性分数（FA）较低相关，尽管没有证据表明年龄与BMI相互作用与该束FA相关。在控制人口统计学变量后，没有观察到BMI与其他白色物质束或认知之间的关系。研究结果表明，BMI升高与连接额叶和颞叶的大脑区域的结构完整性降低有关，这种改变先于认知功能障碍。未来的研究应探讨介导BMI和白色束完整性之间关系的生物学机制，以及利用纵向设计研究这些异常的演变。
Obesity, commonly measured with body mass index (BMI), is associated with numerous deleterious health conditions including alterations in brain integrity related to advanced age. Prior research has suggested that white matter integrity observed using diffusion tensor imaging (DTI) is altered in relation to high BMI, but the integrity of specific white matter tracts remains poorly understood. Additionally, no studies have examined white matter tract integrity in conjunction with neuropsychological evaluation associated with BMI among older adults. The present study examined white matter tract integrity using DTI and cognitive performance associated with BMI in 62 healthy older adults (20 males, 42 females) aged 51 to 81. Results revealed that elevated BMI was associated with lower fractional anisotropy (FA) in the uncinate fasciculus, though there was no evidence of an age by BMI interaction relating to FA in this tract. No relationships were observed between BMI and other white matter tracts or cognition after controlling for demographic variables. Findings suggest that elevated BMI is associated with lower structural integrity in a brain region connecting frontal and temporal lobes and this alteration precedes cognitive dysfunction. Future studies should examine biological mechanisms that mediate the relationships between BMI and white matter tract integrity, as well as the evolution of these abnormalities utilizing longitudinal designs.
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影响因子：
120.7
作者：
Flegal, Katherine M.;Carroll, Margaret D.;Curtin, Lester R.
通讯作者：
Curtin, Lester R.
影响因子：
5.7
作者：
Jenkinson, M;Bannister, P;Smith, S
通讯作者：
Smith, S
影响因子：
9.9
作者：
Cournot, M.;Marquie, J. -C.;Ruidavets, J. -B.
通讯作者：
Ruidavets, J. -B.
影响因子：
3.7
作者：
Bettcher, Brianne Magouirk;Walsh, Christine M.;Kramer, Joel H.
通讯作者：
Kramer, Joel H.
健康老年人中体重指数对神经元纤维束长度的影响。
影响因子：
3.2
作者：
Bolzenius, Jacob D.;Laidlaw, David H.;Cabeen, Ryan P.;Conturo, Thomas E.;McMichael, Amanda R.;Lane, Elizabeth M.;Heaps, Jodi M.;Salminen, Lauren E.;Baker, Laurie M.;Gunstad, John;Paul, Robert H.
通讯作者：
Paul, Robert H.