Distinguishing Between Treatment-Resistant and Non-Treatment-Resistant Schizophrenia Using Regional Homogeneity.
Distinguishing Between Treatment-Resistant and Non-Treatment-Resistant Schizophrenia Using Regional Homogeneity.
复制标题
利用区域同质性区分难治性和非难治性精神分裂症
DOI：
10.3389/fpsyt.2018.00282
复制
发表时间：
2018
影响因子：
4.7
通讯作者：
Xu X
中科院分区：
文献类型：
--
作者：
Gao S;Lu S;Shi X;Ming Y;Xiao C;Sun J;Yao H;Xu X
背景资料：难治性精神分裂症（TRS）和非难治性精神分裂症（NTRS）患者对抗精神病药物的反应不同。以往的研究表明，TRS或NTRS患者在不同的大脑区域表现出异常的神经活动。因此，在本研究中，我们检验了区域同质性（ReHo）方法可用于区分TRS和NTRS患者的假设。研究方法：共招募了17例TRS患者，17例NTRS患者和29例性别，年龄和教育水平匹配的健康对照（HC）进行静息态功能磁共振成像（RS-fMRI）。ReHo用于处理数据。数据分析采用协方差分析、事后t检验、受试者工作特征曲线（ROC）和相关性分析。结果：ANCOVA分析显示，三组之间在枕叶、额叶、颞叶和顶叶的ReHo存在广泛差异。ROC分析结果显示，左中央后回、左额下回/三角区和右梭状回的ReHo值区分TRS与NTRS、TRS与HC、NTRS与HC的最佳灵敏度和特异度分别为94.12和82.35%，100和86.21%，82.35和93.10%。TRS和NTRS患者的ReHo异常与临床症状无相关性。结论：TRS和NTRS的异常神经活动区大部分相同。某些脑区的ReHo值异常可用于鉴别TRS与NTRS、TRS与HC、NTRS与HC，具有较高的敏感性和特异性。
Background: Patients with treatment-resistant schizophrenia (TRS) and non-treatment-resistant schizophrenia (NTRS) respond to antipsychotic drugs differently. Previous studies demonstrated that patients with TRS or NTRS exhibited abnormal neural activity in different brain regions. Accordingly, in the present study, we tested the hypothesis that a regional homogeneity (ReHo) approach could be used to distinguish between patients with TRS and NTRS. Methods: A total of 17 patients with TRS, 17 patients with NTRS, and 29 healthy controls (HCs) matched in sex, age, and education levels were recruited to undergo resting-state functional magnetic resonance imaging (RS-fMRI). ReHo was used to process the data. ANCOVA followed by post-hoc t-tests, receiver operating characteristic curves (ROC), and correlation analyses were applied for the data analysis. Results: ANCOVA analysis revealed widespread differences in ReHo among the three groups in the occipital, frontal, temporal, and parietal lobes. ROC results indicated that the optimal sensitivity and specificity of the ReHo values in the left postcentral gyrus, left inferior frontal gyrus/triangular part, and right fusiform could differentiate TRS from NTRS, TRS from HCs, and NTRS from HCs were 94.12 and 82.35%, 100 and 86.21%, and 82.35 and 93.10%, respectively. No correlation was found between abnormal ReHo and clinical symptoms in patients with TRS or NTRS. Conclusions: TRS and NTRS shared most brain regions with abnormal neural activity. Abnormal ReHo values in certain brain regions might be applied to differentiate TRS from NTRS, TRS from HC, and NTRS from HC with high sensitivity and specificity.
登录
查看更多内容
精神分裂症患者半球间协调能力下降：静息态功能磁共振成像研究
影响因子：
4.5
作者：
Hoptman MJ;Zuo XN;D'Angelo D;Mauro CJ;Butler PD;Milham MP;Javitt DC
通讯作者：
Javitt DC
影响因子：
4.8
作者：
Jeong, Bumseok;Wible, Cynthia G.;Hashimoto, Ryu-ichiro;Kubicki, Marek
通讯作者：
Kubicki, Marek
影响因子：
17.7
作者：
Jardri, Renaud;Pouchet, Alexandre;Thomas, Pierre
通讯作者：
Thomas, Pierre
首发未用药精神分裂症静息时因结构性缺陷导致的异常因果连接
影响因子：
6.6
作者：
Guo, Wenbin;Liu, Feng;Zhao, Jingping
通讯作者：
Zhao, Jingping
影响因子：
4
作者：
Dragovic, Milan;Hammond, Geoff
通讯作者：
Hammond, Geoff