Nucleus basalis stimulation enhances working memory by stabilizing stimulus representations in primate prefrontal cortical activity.
Nucleus basalis stimulation enhances working memory by stabilizing stimulus representations in primate prefrontal cortical activity.
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DOI：
10.1016/j.celrep.2021.109469
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发表时间：
2021-08-03
期刊：
影响因子：
8.8
通讯作者：
Constantinidis C
中科院分区：
文献类型：
--
作者：
Qi XL;Liu R;Singh B;Bestue D;Compte A;Vazdarjanova AI;Blake DT;Constantinidis C
乙酰胆碱在新皮层中起着至关重要的作用。胆碱能激动剂和乙酰胆碱酯酶抑制剂可以增强认知功能，间歇性电刺激乙酰胆碱的皮质来源，Meynert基底核（NB）。在这里，我们显示在两个雄性猴子如何NB刺激影响工作记忆和改变其神经代码。NB刺激增加背外侧前额叶活动的空间工作记忆任务的延迟期间，并扩大了刺激的选择性，但不加强相位响应每个神经元的最佳视觉刺激。奇怪的是，尽管神经元的选择性降低，但在许多任务条件下，性能提高，可能表明延迟期稳定性增加。NB刺激下的性能下降，如果类似的干扰目标，符合减少前额叶的选择性。我们的研究结果表明，刺激胆碱能前脑增加前额叶神经活动，这种神经调节音可以提高认知能力，受到稳定性准确性的权衡。Qi等人表明，间歇性电刺激Meynert基底核（大脑皮层胆碱能神经支配的来源）可改善工作记忆任务的表现。NB刺激增加了背外侧前额叶神经元的活动并扩大了调谐，使维持记忆中信息的网络更加稳定。
Acetylcholine plays a critical role in the neocortex. Cholinergic agonists and acetylcholinesterase inhibitors can enhance cognitive functioning, as does intermittent electrical stimulation of the cortical source of acetylcholine, the nucleus basalis (NB) of Meynert. Here we show in two male monkeys how NB stimulation affects working memory and alters its neural code. NB stimulation increases dorsolateral prefrontal activity during the delay period of spatial working memory tasks and broadens selectivity for stimuli but does not strengthen phasic responses to each neuron’s optimal visual stimulus. Paradoxically, despite this decrease in neuronal selectivity, performance improves in many task conditions, likely indicating increased delay period stability. Performance under NB stimulation does decline if distractors similar to the target are presented, consistent with reduced prefrontal selectivity. Our results indicate that stimulation of the cholinergic forebrain increases prefrontal neural activity, and this neuromodulatory tone can improve cognitive performance, subject to a stability-accuracy tradeoff. Qi et al. show that intermittent electrical stimulation of the nucleus basalis of Meynert, the source of cholinergic innervation of the cerebral cortex, improves performance in working memory tasks. NB stimulation increases activity of dorsolateral prefrontal neurons and broadens tuning, making the network that maintains information in memory more stable.
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影响因子：
25
作者：
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通讯作者：
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影响因子：
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