MYB exhibits racially disparate expression, clinicopathologic association, and predictive potential for biochemical recurrence in prostate cancer.
MYB exhibits racially disparate expression, clinicopathologic association, and predictive potential for biochemical recurrence in prostate cancer.
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MYB在前列腺癌中表现出种族差异表达、临床病理学关联和生化复发的预测潜力。
DOI：
10.1016/j.isci.2023.108487
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发表时间：
2023-12-15
期刊：
影响因子：
5.8
通讯作者：
Singh, Ajay Pratap
中科院分区：
文献类型：
--
作者：
Khan, Mohammad Aslam;Acharya, Srijan;Anand, Shashi;Sameeta, Fnu;Pramanik, Paramahansa;Keel, Christopher;Singh, Seema;Carter, James Elliot;Dasgupta, Santanu;Singh, Ajay Pratap
MYB通过异常激活雄激素受体（AR）信号，在前列腺癌（PCa）中发挥侵袭性和去势抵抗的增强作用。由于黑人男性的前列腺癌发病率和死亡率高于白人男性，我们研究了这些种族背景的患者前列腺肿瘤中MYB的表达是否存在差异。数据显示，MYB的异常表达在癌前高级别前列腺上皮内肿瘤病变中早期开始，并在恶性细胞中逐渐增加。在总体和分级比较中，黑人患者的前列腺癌组织MYB表达高于白人患者。MYB与AR表达也呈正相关，且在肿瘤晚期均有较高表达。值得注意的是，我们发现MYB比AR、治疗前PSA或Gleason分级更能预测生化复发。这些发现表明MYB是前列腺癌的一个有希望的分子靶点，可用于改善风险预测和治疗计划。MYB在前列腺癌中异常表达，随着肿瘤分级的进展，MYB的表达逐渐增加，黑人患者MYB的表达高于白人患者MYB是一个有希望预测生化复发的生物标志物；分子生物学;癌症
MYB acts as a potentiator of aggressiveness and castration resistance in prostate cancer (PCa) through aberrant activation of androgen receptor (AR) signaling. Since Black men experience higher PCa incidence and mortality than White men, we examined if MYB was differentially expressed in prostate tumors from patients of these racial backgrounds. The data reveal that aberrant MYB expression starts early in precancerous high-grade prostate intraepithelial neoplastic lesions and increases progressively in malignant cells. PCa tissues from Black patients exhibit higher MYB expression than White patients in overall and grade-wise comparisons. MYB also exhibits a positive correlation with AR expression and both display higher expression in advanced tumor stages. Notably, we find that MYB is a better predictor of biochemical recurrence than AR, pre-treatment PSA, or Gleason’s grades. These findings establish MYB as a promising molecular target in PCa that could be used for improved risk prediction and therapeutic planning. MYB is aberrantly expressed in prostate cancer MYB expression increases progressively correlating with the advancing tumor grades A higher MYB expression is detected in Black patients than in White patients MYB is a promising predictive biomarker of biochemical recurrence Health disparity; Molecular biology; Cancer
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影响因子：
5.2
作者：
Saranyutanon S;Deshmukh SK;Dasgupta S;Pai S;Singh S;Singh AP
通讯作者：
Singh AP
前列腺癌的种族差异：分子视角。
DOI：
10.2741/4515
发表时间：
2017-01-01
期刊：
Frontiers in bioscience (Landmark edition)
影响因子：
--
作者：
Bhardwaj A;Srivastava SK;Khan MA;Prajapati VK;Singh S;Carter JE;Singh AP
通讯作者：
Singh AP
影响因子：
3.4
作者：
Bluemn EG;Nelson PS
通讯作者：
Nelson PS
影响因子：
--
作者：
Hong SK
通讯作者：
Hong SK
影响因子：
28.2
作者：
Smeenk L;Ottema S;Mulet-Lazaro R;Ebert A;Havermans M;Varea AA;Fellner M;Pastoors D;van Herk S;Erpelinck-Verschueren C;Grob T;Hoogenboezem RM;Kavelaars FG;Matson DR;Bresnick EH;Bindels EM;Kentsis A;Zuber J;Delwel R
通讯作者：
Delwel R