Changes in Cell-Mediated Immunity (IFN-γ and Granzyme B) Following Influenza Vaccination.
Changes in Cell-Mediated Immunity (IFN-γ and Granzyme B) Following Influenza Vaccination.
复制标题
流感疫苗接种后细胞免疫(干扰素-γ和颗粒酶B)的变化
DOI：
10.3390/v13061137
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发表时间：
2021-06-13
期刊：
影响因子：
--
通讯作者：
Okuno T
中科院分区：
文献类型：
--
作者：
Otani N;Nakajima K;Ishikawa K;Ichiki K;Ueda T;Takesue Y;Yamamoto T;Tanimura S;Shima M;Okuno T
干扰素γ（IFN-γ）被认为是细胞介导的免疫的关键调节剂。然而，很少有人知道它与颗粒酶B，这在细胞毒性T淋巴细胞（CTL）的效应功能中起着重要作用。本研究采集了32名健康成年人在2017/18年度接种流感灭活疫苗前后的血液样本，检测在细胞免疫中发挥作用的IFN-γ和颗粒酶B水平，以及在体液免疫中发挥作用的血凝抑制（HAI）抗体水平。免疫前后IFN-γ和颗粒酶B水平呈显著相关。此外，IFN-γ和颗粒酶B水平的疫苗后倍数增加显著相关。超过一半的受试者在接种疫苗后5个月时IFN-γ和颗粒酶B水平下降，这些受试者在接种疫苗后2周时IFN-γ和颗粒酶B水平升高。这是首次研究流感疫苗接种后IFN-γ和颗粒酶B水平之间的相关性。本研究提示IFN-γ和颗粒酶B均可作为细胞免疫的标志物。
Interferon gamma (IFN-γ) is considered a key moderator of cell-mediated immunity. However, little is known about its association with granzyme B, which plays an important role in the effector function of cytotoxic T lymphocytes (CTLs). In the present study, we collected blood samples from 32 healthy adults before and after vaccination with inactivated influenza vaccine in 2017/18 to measure the levels of IFN-γ and granzyme B, which play roles in cell-mediated immunity, and hemagglutination inhibition (HAI) antibody, which plays a role in humoral immunity. The levels of IFN-γ and granzyme B were significantly correlated both before and after vaccination. Furthermore, the post-vaccine fold increases in the IFN-γ and granzyme B levels were significantly correlated. The levels of IFN-γ and granzyme B decreased five months after vaccination in more than half of the subjects who exhibited an increase in IFN-γ and granzyme B at two weeks post-vaccination. This is the first study to investigate the correlation between IFN-γ and granzyme B levels following influenza vaccination. Our study suggests that both IFN-γ and granzyme B can be used as markers of cell-mediated immunity.
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影响因子：
5.5
作者：
McElhaney, JE;Hooton, JW;Bleackley, RC
通讯作者：
Bleackley, RC
影响因子：
5.5
作者：
McElhaney, Janet E.;Ewen, Catherine;Bleackley, R. Chris
通讯作者：
Bleackley, R. Chris
DOI：
10.15585/mmwr.mm6722a4
发表时间：
2018-06-08
期刊：
MMWR. Morbidity and mortality weekly report
影响因子：
--
作者：
Garten R;Blanton L;Elal AIA;Alabi N;Barnes J;Biggerstaff M;Brammer L;Budd AP;Burns E;Cummings CN;Davis T;Garg S;Gubareva L;Jang Y;Kniss K;Kramer N;Lindstrom S;Mustaquim D;O'Halloran A;Sessions W;Taylor C;Xu X;Dugan VG;Fry AM;Wentworth DE;Katz J;Jernigan D
通讯作者：
Jernigan D
影响因子：
5.5
作者：
Mbawuike, I.;Zang, Y.;Couch, R. B.
通讯作者：
Couch, R. B.
影响因子：
4.8
作者：
Kumar, Arun;McElhaney, Janet E.;Scheifele, David W.
通讯作者：
Scheifele, David W.