Alternative Therapeutic Interventions: Antimicrobial Peptides and Small Molecules to Treat Microbial Keratitis.
Alternative Therapeutic Interventions: Antimicrobial Peptides and Small Molecules to Treat Microbial Keratitis.
复制标题
DOI：
10.3389/fchem.2021.694998
复制
发表时间：
2021
影响因子：
5.5
通讯作者：
Roy S
中科院分区：
文献类型：
--
作者：
Jadi PK;Sharma P;Bhogapurapu B;Roy S
微生物性角膜炎是全球范围内致盲的主要原因，估计每年有200万人单侧视力丧失。细菌和真菌是引起角膜溃疡的两种主要病原体。虽然抗生素和抗真菌药通常用于治疗角膜感染，但对这些抗菌药物的耐药性正在迅速增加。已经进行了广泛的研究，以确定替代的治疗干预措施，抗菌肽（AMP）越来越多地认识到其在治疗感染的临床潜力。针对病原体和天然化合物的毒力因子的小分子也被探索以满足治疗剂的挑战和日益增长的需求。在这里，我们回顾了AMP，小分子和天然化合物作为角膜感染治疗的替代治疗干预措施，以对抗抗菌素耐药性的潜力。此外，我们还讨论了不同形式的药物输送系统，以最佳的药物管理，以治疗微生物角膜炎。
Microbial keratitis is a leading cause of blindness worldwide and results in unilateral vision loss in an estimated 2 million people per year. Bacteria and fungus are two main etiological agents that cause corneal ulcers. Although antibiotics and antifungals are commonly used to treat corneal infections, a clear trend with increasing resistance to these antimicrobials is emerging at rapid pace. Extensive research has been carried out to determine alternative therapeutic interventions, and antimicrobial peptides (AMPs) are increasingly recognized for their clinical potential in treating infections. Small molecules targeted against virulence factors of the pathogens and natural compounds are also explored to meet the challenges and growing demand for therapeutic agents. Here we review the potential of AMPs, small molecules, and natural compounds as alternative therapeutic interventions for the treatment of corneal infections to combat antimicrobial resistance. Additionally, we have also discussed about the different formats of drug delivery systems for optimal administration of drugs to treat microbial keratitis.
登录
查看更多内容
影响因子：
2.1
作者：
Bocchinfuso, Gianfranco;Palleschi, Antonio;Stella, Lorenzo
通讯作者：
Stella, Lorenzo
影响因子：
3.5
作者：
Bailey, Leslie;Gylfe, Asa;Bergstrom, Sven
通讯作者：
Bergstrom, Sven
影响因子：
6.7
作者：
Ahsan, Saad M.;Rao, Ch. Mohan
通讯作者：
Rao, Ch. Mohan
影响因子：
3.2
作者：
Bazzaz, Bibi Sedigheh Fazly;Khameneh, Bahman;Mohajeri, Seyed Ahmad
通讯作者：
Mohajeri, Seyed Ahmad
影响因子：
--
作者：
Abd Ghafar, Norzana;Ker-Woon, Choy;Ngah, Wan Zurinah Wan
通讯作者：
Ngah, Wan Zurinah Wan