Resveratrol levels and all-cause mortality in older community-dwelling adults.
Resveratrol levels and all-cause mortality in older community-dwelling adults.
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DOI：
10.1001/jamainternmed.2014.1582
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发表时间：
2014-07
影响因子：
39
通讯作者：
Andres-Lacueva, Cristina
中科院分区：
文献类型：
--
作者：
Semba, Richard D.;Ferrucci, Luigi;Bartali, Benedetta;Urpi-Sarda, Mireia;Zamora-Ros, Raul;Sun, Kai;Cherubini, Antonio;Bandinelli, Stefania;Andres-Lacueva, Cristina
白藜芦醇是一种多酚，存在于葡萄、红酒、巧克力和某些浆果和根中，被认为对人类具有抗氧化、抗炎和抗癌作用，并与一些低等生物的长寿有关。确定饮食中达到的白藜芦醇水平是否与人类的炎症、癌症、心血管疾病和死亡率有关。前瞻性队列研究，Invecchiare in Chianti（InCHIANTI）研究（“基安蒂地区的老龄化”），1998-2009年。意大利托斯卡纳地区基安蒂地区的两个村庄。以人群为基础的样本，783名社区居住的男性和女性，≥65岁，24小时尿白藜芦醇代谢产物主要结局指标是全因死亡率。次要结果是炎症标志物（血清C-反应蛋白[CRP]、白细胞介素[IL]-6、IL-1β和肿瘤坏死因子[TNF]-α），以及患病和发病的癌症和心血管疾病平均（95%置信区间）log总尿白藜芦醇代谢物浓度为7.08（6.69，7.48）nmol/g肌酐。在9年的随访中，268名（34.3%）参与者死亡。从基线尿白藜芦醇代谢物总量的最低到最高四分位数，死于所有原因的参与者比例分别为34.4%、31.6%、33.5%和37.4%（P = 0.67）。在校正潜在混杂因素的多变量考克斯比例风险模型中，与尿白藜芦醇总量最高四分位数的参与者相比，最低四分位数的参与者死亡率风险比为0.80（95%置信区间0.54，1.17）。白藜芦醇水平与血清CRP、IL-6、IL-1β、TNF-α、流行或偶发心血管疾病或癌症无显著相关性。结论：在老年社区居民中，总尿白藜芦醇代谢物浓度与炎症标志物、心血管疾病或癌症无关，也不能预测全因死亡率。用西方饮食达到的白藜芦醇水平对健康状况和死亡风险没有实质性影响。
Resveratrol, a polyphenol found in grapes, red wine, chocolate, and certain berries and roots, is considered to have antioxidant, anti-inflammatory, and anti-cancer effects in humans and is related to longevity in some lower organisms. To determine whether resveratrol levels achieved with diet are associated with inflammation, cancer, cardiovascular disease, and mortality in humans. Prospective cohort study, the Invecchiare in Chianti (InCHIANTI) Study (“Aging in the Chianti Region”), 1998-2009. Two villages in the Chianti area, Tuscany region of Italy. Population-based sample of 783 community-dwelling men and women, ≥65 y 24-h urinary resveratrol metabolites Primary outcome measure was all-cause mortality. Secondary outcomes were markers of inflammation (serum C-reactive protein [CRP], interleukin [IL]-6, IL-1β, and tumor necrosis factor [TNF]-α), and prevalent and incident cancer and cardiovascular disease Mean (95% Confidence Interval) log total urinary resveratrol metabolite concentrations were 7.08 (6.69, 7.48) nmol/g creatinine. During nine years of follow-up, 268 (34.3%) of the participants died. From the lowest to the highest quartile of baseline total urinary resveratrol metabolites, the proportion of participants who died from all causes was 34.4, 31.6, 33.5, and 37.4%, respectively (P = 0.67). Participants in the lowest quartile had a hazards ratio for mortality of 0.80 (95% confidence interval 0.54, 1.17) when compared with those in the highest quartile of total urinary resveratrol in a multivariable Cox proportional hazards model that adjusted for potential confounders. Resveratrol levels were not significantly associated with serum CRP, IL-6, IL-1β, TNF-α, prevalent or incident cardiovascular disease or cancer. Conclusions: In older community-dwelling adults, total urinary resveratrol metabolite concentration was not associated with inflammatory markers, cardiovascular disease, or cancer, or predictive of all-cause mortality. Resveratrol levels achieved with a Western diet do not have a substantial influence on health status and mortality risk.
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DOI：
10.18632/aging.100445
发表时间：
2012-03
期刊：
Aging
影响因子：
--
作者：
Timmers S;Auwerx J;Schrauwen P
通讯作者：
Schrauwen P
影响因子：
5.8
作者：
Ghanim, Husam;Sia, Chang Ling;Dandona, Paresh
通讯作者：
Dandona, Paresh
DOI：
10.1111/j.1532-5415.2000.tb03873.x
发表时间：
2000-12-01
影响因子：
6.3
作者：
Ferrucci, L;Bandinelli, S;Guralnik, JM
通讯作者：
Guralnik, JM
影响因子：
20.3
作者：
Ferrucci, L;Corsi, A;Longo, DL
通讯作者：
Longo, DL
影响因子：
5.2
作者：
Tome-Carneiro, Joao;Gonzalvez, Manuel;Carlos Espin, Juan
通讯作者：
Carlos Espin, Juan