Ca2+ and cAMP signaling pathways interact to increase the diuretic effect of serotonin in Malpighian tubules of the kissing bug. Focus on "Serotonin triggers cAMP- and PKA-1-mediated intracellular calcium waves in Malpighian tubules of Rhodnius prolixus".
Ca2+ and cAMP signaling pathways interact to increase the diuretic effect of serotonin in Malpighian tubules of the kissing bug. Focus on "Serotonin triggers cAMP- and PKA-1-mediated intracellular calcium waves in Malpighian tubules of Rhodnius prolixus".
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Ca2 和 cAMP 信号通路相互作用，增加接吻虫马氏小管中血清素的利尿作用。
DOI：
10.1152/ajpregu.00336.2014
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Beyenbach,KlausW
中科院分区：
文献类型：
--
作者：
Pannabecker,ThomasL;Beyenbach,KlausW
20多年前，人们对昆虫马氏管中离子运输的动力进行了令人着迷的探索，最终发现驱动这个器官中电解质(8，18)以及有机溶质的跨上皮运输的是液泡型H+ATPase，而不是Na+-K+-ATPase。液泡型H+ATPase产生的H+梯度反过来驱动一个或多个阳离子/H+逆向转运体(NHAs)，这些转运体与各种顶端和基底侧膜离子转运体和水通道一起，导致各种昆虫上皮细胞的跨上皮离子通量和水分的分泌或吸收。众所周知，5-羟色胺可以调节昆虫上皮细胞的液体和离子运输，如唾液腺和马氏管(2)。事实上，许多关于肌醇磷脂作为细胞功能调节剂的开创性研究都是在昆虫的唾液腺中进行的。与5-羟色胺相关的其他信号转导途径包括细胞内环核苷酸和钙离子浓度的变化。环磷酸腺苷的增加和胞浆钙离子的变化可能导致膜蛋白的翻译后修饰，从而通过明显的协同机制带来跨上皮电解质和液体分泌的最大速率。普氏罗氏吸血虫，携带导致恰加斯病的原生动物克氏锥虫，在血餐后经历快速利尿。利尿至少部分受促肾上腺皮质激素释放激素相关肽和5-羟色胺(9，16)的调节，两者都与马氏管上的质膜受体结合，导致离子和液体分泌速度增加。5-羟色胺的作用是通过环磷酸腺苷、钙离子和磷脂酰肌醇的信号级联反应来实现的，这些信号通路依次和/或结合地引起跨皮细胞溶质的利尿率和水的流动。Gioino等人最近在美国的一项研究(7A)
IT’S BEEN OVER TWO DECADES SINCE a captivating search for what powers ion transport in the insect Malpighian tubule culminated in the discovery that the vacuolar-type H+ ATPase, and not the Na+-K+-ATPase, drives transepithelial transport of electrolytes (8, 18) and probably also organic solutes in this organ. The H+ gradient generated by the vacuolar-type H+ ATPase, in turn, drives one or more cation/H+ antiporters (NHAs), which, along with a varied assortment of apical and basolateral membrane ion transporters and water channels, leads to transepithelial ion fluxes and water secretion or absorption in various insect epithelia. Serotonin has long been known to regulate fluid and ion transport in insect epithelia, such as the salivary gland and the Malpighian tubule (2). In fact, many of the pioneering studies on the role of phosphoinositides as regulators of cell function were carried out in the insect salivary gland (1). Other signal transduction pathways associated with serotonin include alterations in intracellular cyclic nucleotide and Ca2+ concentrations. Increases in cyclic AMP and changes in cytoplasmic Ca2+ likely lead to the posttranslational modifications of membrane proteins that bring about maximal rates of transepithelial electrolyte and fluid secretion by apparently synergistic mechanisms.Rhodnius prolixus, the blood-sucking “kissing bug” that carries the protozoan Trypanosoma cruzi, which causes Chagas disease, undergoes rapid diuresis following a blood meal. Diuresis is regulated, at least in part, by a corticotropinreleasing hormone-related peptide and serotonin (9, 16), both of which bind to plasma membrane receptors in the Malpighian tubule and lead to enhanced rates of ion and fluid secretion. Serotonin elicits its effects by way of signaling cascades involving cyclic AMP, Ca2+, and phosphoinositides, which in sequence and/or combination bring about diuretic rates of transepithelial solute and water flow. A recent study by Gioino et al.(7a) in the American
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影响因子：
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作者：
M. Verani;N. Zacca;R. Miller;R. Luchi;R. Chahine
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DOI：
10.1016/0002-9149(82)90305-8
发表时间：
1982
期刊：
The American journal of cardiology
影响因子：
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DOI：
10.1016/0002-9149(81)90399-4
发表时间：
1981
期刊：
The American journal of cardiology
影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/0002-9149(81)90400-8
发表时间：
1981
期刊：
The American journal of cardiology
影响因子：
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作者：
W. Lam;D. Pavel;E. Byrom;A. Sheikh;D. Best;K. Rosen
通讯作者：
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通过门控心脏血池扫描测量主动脉和二尖瓣反流
影响因子：
37.8
作者：
P. Rigo;P. Alderson;R. Robertson;L. Becker;H. Wagner
通讯作者：
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