Drug release from calcium sulfate-based composites.
Drug release from calcium sulfate-based composites.
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DOI：
10.1002/jbm.b.33181
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发表时间：
2015-01
影响因子：
3.4
通讯作者：
Puleo, David A.
中科院分区：
文献类型：
--
作者：
Orellana, Bryan R.;Hilt, J. Zach;Puleo, David A.
为了帮助减少对自体移植物的需求，正在开发基于硫酸钙的骨移植替代物，以提供稳定的平台来帮助增强，同时能够释放广泛的生物活性剂。硫酸钙（CS）作为生物相容性和骨传导性物质具有良好的声誉，但添加生物活性剂可能会进一步增强这些特性。用直接加载的小的疏水分子（即，辛伐他汀），直接负载的亲水性蛋白质（即，溶菌酶）或1和10重量%的含蛋白质的H6聚（β-氨基酯）（PBAE）颗粒。而直接加载的辛伐他汀实现了持续释放，直接加载少量的溶菌酶导致高度可变的释放。直接加载大量的蛋白质产生了一个大的爆发，总负载的65%，然后持续释放蛋白质。从1重量%的PBAE颗粒嵌入到CS中的溶菌酶的释放比直接加载时更可控，并且对于10重量%的蛋白质加载的PBAE颗粒，更高的突释之后是持续释放，与高直接加载的结果相当。压缩测试确定掺入直接加载的药物或加载药物的PBAE颗粒削弱CS。特别是，PBAE颗粒对复合材料的强度有显着的影响，对于1重量%和10重量%的颗粒负载量，强度分别降低25%和80%。CS基复合材料表现出可持续释放大分子和小分子的能力，支持这些材料释放一系列治疗剂的潜力。
To help reduce the need for autografts, calcium sulfate-based bone graft substitutes are being developed to provide a stable platform to aid augmentation while having the ability to release a broad range of bioactive agents. Calcium sulfate (CS) has an excellent reputation as a biocompatible and osteoconductive substance, but addition of bioactive agents may further enhance these properties. Samples were produced with either directly loaded small, hydrophobic molecule (i.e., simvastatin), directly loaded hydrophilic protein (i.e., lysozyme), or 1 and 10 wt% of H6 poly(β-amino ester) (PBAE) particles containing protein. Whereas sustained release of directly loaded simvastatin was achieved, direct loading of small amounts of lysozyme resulted in highly variable release. Direct loading of a larger amount of protein generated a large burst, 65% of total loading, followed by sustained release of protein. Release of lysozyme from 1 wt% PBAE particles embedded into CS was more controllable than when directly loaded, and for 10 wt% of protein-loaded PBAE particles, a higher burst was followed by sustained release, comparable to the results for the high direct loading. Compression testing determined that incorporation of directly loaded drug or drug-loaded PBAE particles weakened CS. In particular, PBAE particles had a significant effect on the strength of the composites, with a 25% and 80% decrease in strength for 1 wt% and 10 wt% particle loadings, respectively. CS-based composites demonstrated the ability to sustainably release both macromolecules and small molecules, supporting the potential for these materials to release a range of therapeutic agents.
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影响因子：
4.3
作者：
Chiapasco, Matteo;Zaniboni, Marco;Rimondini, Lia
通讯作者：
Rimondini, Lia
影响因子：
10.8
作者：
Burdick, JA;Mason, MN;Anseth, KS
通讯作者：
Anseth, KS
影响因子：
2.4
作者：
Cho, Dae-Chul;Kim, Kyoung-Tae;Sung, Joo-Kyung
通讯作者：
Sung, Joo-Kyung
影响因子：
9.7
作者：
Hawkins, Ashley M.;Milbrandt, Todd A.;Hilt, J. Zach
通讯作者：
Hilt, J. Zach
影响因子：
4.3
作者：
Guarnieri, R;Pecora, G;Piattelli, A
通讯作者：
Piattelli, A