Do the right thing: neural network mechanisms of memory formation, expression and update in Drosophila.
Do the right thing: neural network mechanisms of memory formation, expression and update in Drosophila.
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DOI：
10.1016/j.conb.2017.12.002
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发表时间：
2018-04
影响因子：
5.7
通讯作者：
Waddell S
中科院分区：
文献类型：
--
作者：
Cognigni P;Felsenberg J;Waddell S
复现连接在解剖和功能上普遍存在于飞行记忆回路中。持续的回响活动对于巩固记忆是必要的。前馈抑制神经元对记忆提取和行为施加状态控制。循环电路允许重新评估和更新记忆。当动物学习时，大脑网络中对特定线索做出反应的可塑性会导致这些线索引发的行为发生变化。果蝇蘑菇体中的单个网络组件代表了学习经验的线索、学习信号和行为结果。最近的发现强调了在蘑菇体神经网络的不同元素之间的反馈和前馈连接中，多巴胺驱动的可塑性和活动的重要性。这些计算主题已被证明对长期的嗅觉记忆巩固、内部状态的整合、重新评估和学习信息的更新至关重要。经常反复出现的回路解剖结构和对这些潜在网络的部分活动的长期需求表明，自我维持和精确计时的活动是昆虫大脑网络计算的基本特征。这些过程一起允许苍蝇不断地调整它们所学知识的内容，并以最能代表所学期望并满足它们最紧迫的当前需求的方式指导它们的行为。
Recurrent connectivity is anatomically and functionally prevalent in fly memory circuits. Sustained reverberant activity is necessary for memory consolidation. Feedforward inhibitory neurons impose state control on memory retrieval and behavior. Recurrent circuits enable re-evaluation and updating of memory. When animals learn, plasticity in brain networks that respond to specific cues results in a change in the behavior that these cues elicit. Individual network components in the mushroom bodies of the fruit fly Drosophila melanogaster represent cues, learning signals and behavioral outcomes of learned experience. Recent findings have highlighted the importance of dopamine-driven plasticity and activity in feedback and feedforward connections, between various elements of the mushroom body neural network. These computational motifs have been shown to be crucial for long term olfactory memory consolidation, integration of internal states, re-evaluation and updating of learned information. The often recurrent circuit anatomy and a prolonged requirement for activity in parts of these underlying networks, suggest that self-sustained and precisely timed activity is a fundamental feature of network computations in the insect brain. Together these processes allow flies to continuously adjust the content of their learned knowledge and direct their behavior in a way that best represents learned expectations and serves their most pressing current needs.
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影响因子：
1.9
作者：
HEISENBERG, M;BORST, A;BYERS, D
通讯作者：
BYERS, D
影响因子：
64.5
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影响因子：
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作者：
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64.5
作者：
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通讯作者：
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16.2
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