The hidden function of egg white antimicrobials: egg weight-dependent effects of avidin on avian embryo survival and hatchling phenotype.
The hidden function of egg white antimicrobials: egg weight-dependent effects of avidin on avian embryo survival and hatchling phenotype.
复制标题
DOI：
10.1242/bio.031518
复制
发表时间：
2018-04-09
期刊：
影响因子：
2.4
通讯作者：
Javůrková V
中科院分区：
文献类型：
--
作者：
Krkavcová E;Kreisinger J;Hyánková L;Hyršl P;Javůrková V
抗生物素蛋白是一种关键的鸡蛋白色抗菌蛋白，具有与生物素（一种必需的生长和免疫细胞前体）的强结合能力。因此，它被认为有一个显着的，但仍然很少探索，对孵化表型的影响。本研究以日本鹌鹑（Coturnix japonica）为模型鸡，研究了实验性增加卵白白色亲和素浓度（AVIDIN+）对孵化成功率、雏鸡形态、孵化后生长性能和先天免疫功能的影响。在对照蛋中，胚胎晚期的胚胎存活概率随着蛋重的增加而增加，但在AVIDIN+蛋中则不然。从较轻的AVIDIN+蛋中孵化的小鸡比从较重的AVIDIN+蛋中孵化的小鸡具有较短的跗骨。这表明在胚胎发生后期，卵白色抗生物素蛋白的增加有利于较轻卵的胚胎存活，但以减小结构体尺寸为代价。6日龄抗生物素蛋白+雏鸡的血浆补体活性随着体重和睑板长度的增加而降低;在对照雏鸡中观察到相反的情况，这意味着较大雏鸡的后期孵化后先天免疫功能受到卵白色抗生物素蛋白浓度增加的损害。在这里，我们记录了一个重要的作用，鸡蛋白色抗菌剂在维持胚胎活力，禽孵化形态和免疫表型。总结：这是第一个实验研究，以评估增加浓度的鸡蛋白色抗菌蛋白亲和素对胚胎活力，孵化的形态和免疫表型的影响在鸟类。
Avidin is a key egg white antimicrobial protein with strong binding capacity for biotin, an essential growth and immune cell precursor. As such, it is assumed to have a pronounced, though still poorly explored, effect on hatchling phenotype. We tested the effect of experimentally increased egg white avidin concentration (AVIDIN+) on hatching success, chick morphology, post-hatching growth performance and innate immune function in a model bird, Japanese quail (Coturnix japonica). Probability of embryo survival in the late embryonic phase increased with increasing egg weight in control eggs, but not in AVIDIN+ eggs. Chicks hatching from lighter AVIDIN+ eggs had a shorter tarsus than chicks hatching from heavier AVIDIN+ eggs. This suggests that an increase in egg white avidin favours embryo survival in lighter eggs during late embryogenesis, but at the expense of reduced structural body size. Plasma complement activity in 6-day-old AVIDIN+ chicks decreased with increasing body mass and tarsus length; the opposite was observed in control chicks, implying that the later post-hatching innate immune function of larger chicks was compromised by an increase in egg white avidin concentration. Here, we document an important role of egg white antimicrobials in maintenance of embryo viability, avian hatchling morphology and immune phenotype. Summary: This is the first experimental study to evaluate the effects of increased concentration of egg white antimicrobial protein avidin on embryo viability, hatchling morphology and immune phenotype in birds.
登录
查看更多内容
DOI：
10.1007/s003600050116
发表时间：
1998-02-01
影响因子：
2
作者：
Finkler, MS;Van Orman, JB;Sotherland, PR
通讯作者：
Sotherland, PR
影响因子：
2.3
作者：
Bonisoli-Alquati, Andrea;Rubolini, Diego;Saino, Nicola
通讯作者：
Saino, Nicola
影响因子：
2.7
作者：
Christensen, VL
通讯作者：
Christensen, VL
影响因子：
--
作者：
Cravens, WW;McGibbon, WH;Sebesta, EE
通讯作者：
Sebesta, EE
DOI：
10.1016/0305-0491(89)90373-8
发表时间：
1989-01-01
影响因子：
2.2
作者：
BUSH, L;WHITE, HB
通讯作者：
WHITE, HB