Clustering of depression and inflammation in adolescents previously exposed to childhood adversity.
Clustering of depression and inflammation in adolescents previously exposed to childhood adversity.
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DOI：
10.1016/j.biopsych.2012.02.034
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发表时间：
2012-07-01
影响因子：
10.6
通讯作者：
Cole, Steve W.
中科院分区：
文献类型：
--
作者：
Miller, Gregory E.;Cole, Steve W.
人们对感染有助于抑郁症的发病机理的兴趣不断增加，而抑郁症患者对合并症的脆弱性，但是，对抑郁症和感染的研究产生了矛盾的发现，促进了这些疾病仅在某些亚组中与某些亚组相关的猜测就像暴露于童年广告的患者一样。
我们研究了147名青少年女性。炎症性生物标志物，C反应蛋白（CRP）和白介素6（IL-6）。家族心理病理学。
多级模型表明，童年广告促进了暴露于儿童时期广告的受试者之间的抑郁症和炎症。烧毁了这些挥之不去的效果是双向的几个月后，即使考虑到抑郁症的耦合和炎症，在没有童年广告的受试者中也不明显。
这些发现表明，儿童广告促进了神经免疫管道的形成，其中一旦建立了大脑和周围的炎症信号，这种馈送会导致抑郁症和感染的耦合，这可能有助于后来的情感困难和生物医学并发症。
There is mounting interest in the hypothesis that inflammation contributes to the pathogenesis of depression, and underlies depressed patients’ vulnerability to comorbid medical conditions. However, research on depression and inflammation has yielded conflicting findings, fostering speculation that these conditions associate only in certain subgroups, like patients exposed to childhood adversity. We studied 147 adolescent females. All were in good health at baseline, but at high risk for depression by virtue of family history and/or cognitive vulnerability. Subjects were assessed every six months for 2.5 years, undergoing diagnostic interviews and venipuncture for measurement of two inflammatory biomarkers, C-reactive protein (CRP) and interleukin-6 (IL-6). Childhood adversity was indexed by parental separation, low socioeconomic status, and familial psychopathology. Multilevel models indicated that childhood adversity promotes clustering of depression and inflammation. Among subjects exposed to high childhood adversity, the transition to depression was accompanied by increases in both CRP and IL-6. The higher CRP remained evident six months later, even after depressive symptoms had abated. These lingering effects were bi-directional, such that among subjects with childhood adversity, high IL-6 forecasted depression six months later, even after concurrent inflammation was considered. This coupling of depression and inflammation was not apparent in subjects without childhood adversity. These findings suggest that childhood adversity promotes the formation of a neuroimmune pipeline, wherein inflammatory signaling between the brain and periphery is amplified. Once established, this pipeline leads to a coupling of depression and inflammation, which may contribute to later affective difficulties and biomedical complications.
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影响因子：
3.3
作者：
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通讯作者：
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影响因子：
10.6
作者：
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通讯作者：
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作者：
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通讯作者：
Danese, Andrea
影响因子：
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作者：
Danese, Andrea;Moffitt, Terrie E.;Harrington, HonaLee;Milne, Barry J.;Polanczyk, Guilherme;Pariante, Carmine M.;Poulton, Richie;Caspi, Avshalom
通讯作者：
Caspi, Avshalom