The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants.
The complete genome, comparative and functional analysis of Stenotrophomonas maltophilia reveals an organism heavily shielded by drug resistance determinants.
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DOI：
10.1186/gb-2008-9-4-r74
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发表时间：
2008-04-17
期刊：
影响因子：
12.3
通讯作者：
Avison MB
中科院分区：
文献类型：
--
作者：
Crossman LC;Gould VC;Dow JM;Vernikos GS;Okazaki A;Sebaihia M;Saunders D;Arrowsmith C;Carver T;Peters N;Adlem E;Kerhornou A;Lord A;Murphy L;Seeger K;Squares R;Rutter S;Quail MA;Rajandream MA;Harris D;Churcher C;Bentley SD;Parkhill J;Thomson NR;Avison MB
完整的嗜麦芽窄养单胞菌基因组序列表明它可以作为抗生素耐药性决定因素的储存库。嗜麦芽窄养单胞菌是黄单胞菌科的一种医院条件致病菌。除了囊性纤维化患者和免疫功能低下患者的痰液外，还从临床和土壤环境中分离出该生物。虽然在系统发育上相对较远，但嗜麦芽葡萄球菌最近的序列亲戚是植物致病性黄单胞菌。嗜麦芽链球菌K279a的基因组为4,851,126 bp，具有高G+C含量。该序列揭示了一种具有显著抗药物和重金属能力的生物体。除了一些基因通过其他机制赋予对不同种类抗菌药物的耐药性外，还存在九种耐药-结节-分裂（RND）型推定的抗菌药物外排系统。功能基因组分析证实了几种新型RND外排泵在耐药中的作用。嗜麦芽葡萄球菌拥有潜在的可移动DNA区域，并编码许多可能参与粘附和生物膜形成的毛和菌毛，这也可能有助于增加抗微生物药物耐药性。抗菌药物耐药基因和可移动遗传元件的发现表明，在临床环境中，生物体可以作为抗菌药物耐药决定因素的储存库，这是一个相当值得关注的问题。
The complete Stenotrophomonas maltophilia genome sequence suggests that it can act as a reservoir of antibiotic resistance determinants. Stenotrophomonas maltophilia is a nosocomial opportunistic pathogen of the Xanthomonadaceae. The organism has been isolated from both clinical and soil environments in addition to the sputum of cystic fibrosis patients and the immunocompromised. Whilst relatively distant phylogenetically, the closest sequenced relatives of S. maltophilia are the plant pathogenic xanthomonads. The genome of the bacteremia-associated isolate S. maltophilia K279a is 4,851,126 bp and of high G+C content. The sequence reveals an organism with a remarkable capacity for drug and heavy metal resistance. In addition to a number of genes conferring resistance to antimicrobial drugs of different classes via alternative mechanisms, nine resistance-nodulation-division (RND)-type putative antimicrobial efflux systems are present. Functional genomic analysis confirms a role in drug resistance for several of the novel RND efflux pumps. S. maltophilia possesses potentially mobile regions of DNA and encodes a number of pili and fimbriae likely to be involved in adhesion and biofilm formation that may also contribute to increased antimicrobial drug resistance. The panoply of antimicrobial drug resistance genes and mobile genetic elements found suggests that the organism can act as a reservoir of antimicrobial drug resistance determinants in a clinical environment, which is an issue of considerable concern.
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影响因子：
11.8
作者：
de Oliveira-Garcia, D;Dall'Agnol, M;Girón, JA
通讯作者：
Girón, JA
影响因子：
3.2
作者：
Fouhy, Yvonne;Scanlon, Karl;Dow, J. Maxwell
通讯作者：
Dow, J. Maxwell
影响因子：
4.4
作者：
Chang, HC;Chen, CR;Weng, SF
通讯作者：
Weng, SF
影响因子：
4.9
作者：
Ferluga, Sara;Bigirimana, Joseph;Venturi, Vittorio
通讯作者：
Venturi, Vittorio
影响因子：
2.1
作者：
da Silva, FR;Vettore, AL;Arruda, P
通讯作者：
Arruda, P