Persistence of mild to moderate atopic dermatitis.
Persistence of mild to moderate atopic dermatitis.
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DOI：
10.1001/jamadermatol.2013.10271
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发表时间：
2014-06
期刊：
影响因子：
10.9
通讯作者：
Margolis, David J.
中科院分区：
文献类型：
--
作者：
Margolis, Jacob S.;Abuabara, Katrina;Bilker, Warren;Hoffstad, Ole;Margolis, David J.
特应性皮炎（AD）是一种常见的儿童疾病，本研究的目的是评估AD的自然史，并确定症状随时间的持续时间。横断面和队列研究。一个全国性的AD儿童长期登记。在儿童湿疹选择性登记（PEER）登记的儿童。儿童皮肤是否在6个月内每隔6个月无AD症状的自我报告结果。7157名受试者参加了PEER研究，总共22,550人年。对4248名儿童进行了至少2年的随访，对2416名儿童进行了至少5年的随访。多种人口统计学和暴露变量与更持久的阿尔茨海默病有关。在每个年龄段（即2至26岁），超过80%的PEER受试者有AD症状和/或正在使用药物治疗他们的AD。直到20岁时，50%的受试者至少有一个终生六个月的症状和无治疗期。根据这项大型纵向队列研究，与AD相关的症状似乎会持续到儿童生命的第二个十年，甚至可能更长。阿尔茨海默病可能是一种终身疾病。
Atopic dermatitis (AD) is a common illness of childhood The goal of this study was to evaluate the natural history of AD and determine the persistence of symptoms over time. A cross-sectional and cohort study. A nation-wide long-term registry of children with AD. Children enrolled in the Pediatric Eczema Elective Registry (PEER). Self-reported outcome of whether or not a child’s skin was AD symptom-free for 6 months at 6 month intervals. 7,157 subjects were enrolled in the PEER study for a total of 22, 550 person-years. At least 2 years of follow-up was observed for 4,248 and at least 5 years of follow-up was observed for 2,416 children. Multiple demographic and exposure variables were associated with more persistent AD. At every age (i.e. 2 to 26 years), more than 80% of PEER subjects had symptoms of AD and/or were using medication to treat their AD. It was not until age 20 years that 50% of subjects had at least one lifetime six-month symptom and treatment free period. Based on this large longitudinal cohort study, symptoms associated with AD appear to persist well into the second decade of a child’s life and likely longer. AD is likely a life-long illness.
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