Development and Validation of a Nomogram Based on Nutritional Indicators and Tumor Markers for Prognosis Prediction of Pancreatic Ductal Adenocarcinoma.
Development and Validation of a Nomogram Based on Nutritional Indicators and Tumor Markers for Prognosis Prediction of Pancreatic Ductal Adenocarcinoma.
复制标题
基于营养指标和肿瘤标志物的列线图的开发和验证，用于胰腺导管腺癌的预后预测
DOI：
10.3389/fonc.2021.682969
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发表时间：
2021
影响因子：
4.7
通讯作者：
Zhou J
中科院分区：
文献类型：
--
作者：
Li H;Zhou F;Cao Z;Tang Y;Huang Y;Li Y;Yi B;Yang J;Du P;Zhu D;Zhou J
Purpose This study aimed to develop and validate a nomogram with preoperative nutritional indicators and tumor markers for predicting prognosis of patients with pancreatic ductal adenocarcinoma (PDAC). Methods We performed a bicentric, retrospective study including 155 eligible patients with PDAC. Patients were divided into a training group (n = 95), an internal validation group (n = 34), an external validation group (n = 26), and an entire validation group (n = 60). Cox regression analysis was conducted in the training group to identify independent prognostic factors to construct a nomogram for overall survival (OS) prediction. The performance of the nomogram was assessed in validation groups and through comparison with controlling nutritional status (CONUT) and prognostic nutrition index (PNI). Results The least absolute shrinkage and selection operator (LASSO) regression, univariate and multivariate Cox regression analysis revealed that serum albumin and lymphocyte count were independent protective factors while CA19-9 and diabetes were independent risk factors. The concordance index (C-index) of the nomogram in the training, internal validation, external validation and entire validation groups were 0.777, 0.769, 0.759 and 0.774 respectively. The areas under curve (AUC) of the nomogram in each group were 0.861, 0.845, 0.773, and 0.814. C-index and AUC of the nomogram were better than those of CONUT and PNI in the training and validation groups. The net reclassification index (NRI), integrated discrimination improvement (IDI) and decision curve analysis showed improvement of accuracy of the nomogram in predicting OS and better net benefit in guiding clinical decisions in comparison with CONUT and PNI. Conclusions The nomogram incorporating four preoperative nutritional and tumor markers including serum albumin concentration, lymphocyte count, CA19-9 and diabetes mellitus could predict the prognosis more accurately than CONUT and PNI and may serve as a clinical decision support tool to determine what treatment options to choose.
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影响因子：
3.7
作者：
Abe, Toshiya;Nakata, Kohei;Nakamura, Masafumi
通讯作者：
Nakamura, Masafumi
影响因子：
2.9
作者：
Kato, Yoshiyasu;Yamada, Suguru;Kodera, Yasuhiro
通讯作者：
Kodera, Yasuhiro
影响因子：
4.8
作者：
Eibl G;Cruz-Monserrate Z;Korc M;Petrov MS;Goodarzi MO;Fisher WE;Habtezion A;Lugea A;Pandol SJ;Hart PA;Andersen DK;Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer
通讯作者：
Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer
影响因子：
5.4
作者：
Gupta D;Lis CG
通讯作者：
Lis CG
影响因子：
1.2
作者：
Nakano, Yutaka;Kitago, Minoru;Kitagawa, Yuko
通讯作者：
Kitagawa, Yuko