Cellular DNA content parameters in untreated and recurrent squamous cell cancers of the head and neck.
Cellular DNA content parameters in untreated and recurrent squamous cell cancers of the head and neck.
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未经治疗和复发的头颈部鳞状细胞癌的细胞 DNA 含量参数。
DOI：
10.1002/cyto.990100313
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
al-Sarraf,M
中科院分区：
文献类型：
--
作者：
Ensley,JF;Maciorowski,Z;Hassan,M;Pietraszkiewicz,H;Heilbrun,L;Kish,JA;Tapazoglou,E;Jacobs,JR;al-Sarraf,M
应用流式细胞术检测了237例头颈部鳞状细胞癌（SCCHN）患者的294份标本中DNA异倍体的存在和程度，并以DNA指数（DI）和S期细胞比例（SPF）为指标。进行描述性分析，其中标本DNA参数与相应患者的分期、原发灶大小、淋巴结受累程度、形态学分级和治疗状态相关。大约70%的先前未处理的标本含有DNA非整倍体群体（DI > 1.10），四分之三的SPF高于15%。DI值与SPF值呈显著正相关（P< 0.001）。DNA非整倍体的存在或程度与肿瘤的分期或原发肿瘤的大小或常规形态学分级无关。来自复发肿瘤患者和未经治疗的N3淋巴结患者的标本的DNA非整倍体率和平均DI显著较低。在接受细胞毒性治疗的SCCHN患者中，DNA非整倍体的系列测定正在进行中，可能有助于识别和理解这种肿瘤的耐药性和反应。
The presence and degree of DNA aneuploidy as measured by the DNA index (DI) and the S phase fraction (SPF) were determined by flow cytometry in 294 specimens from 237 patients with untreated and recurrent squamous cell carcinomas of the head and neck (SCCHN). A descriptive analysis was performed in which the specimen DNA parameters were correlated with stage, size of primary, degree of lymph node involvement, morphological grade, and treatment status of the corresponding patients. Approximately 70% of the previously untreated specimens contained DNA aneuploid populations (DI > 1.10) and three quarters had SPF that were above 15%. There was a strong, direct as sociation between DI and SPF (P< 0.001). There was no correlation of the presence or degree of DNA aneuploidy with the stage of the tumor or the size of the primary or conventional morphological grade of the tumor. Specimens from patients with recurrent tumors and untreated patients with N3lymph nodes had significantly lower rates of DNA aneuploidy and mean DI. Serial determinations of DNA aneuploidy in patients with SCCHN undergoing cytotoxic therapy are ongoing and may prove useful in the identification and understanding of resistance and response in this tumor.
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人鳞状细胞癌细胞系的 DNA 含量。
DOI：
10.1001/archotol.1985.00800110043001
发表时间：
1985
期刊：
Archives of otolaryngology (Chicago, Ill. : 1960)
影响因子：
--
作者：
Roa,RA;Carey,TE;Passamani,PP;Greenwood,JH;Hsu,S;Ridings,EO;Schwartz,DR;Wolf,GT;Hudson,JL
通讯作者：
Hudson,JL
头颈鳞状细胞癌的回顾性 DNA 分析。
DOI：
10.1001/archotol.1986.03780110035003
发表时间：
1986
期刊：
Archives of otolaryngology--head & neck surgery
影响因子：
--
作者：
A. S. Kaplan;D. Caldarelli;M. Chacho;D. Bruce;J. Hutchinson;S. Conway;J. Coon
通讯作者：
J. Coon
头颈部鳞状细胞癌的细胞DNA量与预后的关系
DOI：
10.1288/00005537-198209000-00018
发表时间：
1982
期刊：
The Laryngoscope
影响因子：
--
作者：
L. Holm
通讯作者：
L. Holm
石蜡包埋切片中头颈癌 DNA 指数和 S 组分的流式细胞术分析：与恶性肿瘤分级的比较。
DOI：
10.1002/cyto.990060511
发表时间：
1985
期刊：
Cytometry
影响因子：
--
作者：
Johnson,TS;Williamson,KD;Cramer,MM;Peters,LJ
通讯作者：
Peters,LJ
影响因子：
6.2
作者：
NERVI, C;ARCANGELI, G;STARACE, G
通讯作者：
STARACE, G