Dermatitis during Spaceflight Associated with HSV-1 Reactivation.
Dermatitis during Spaceflight Associated with HSV-1 Reactivation.
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DOI：
10.3390/v14040789
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发表时间：
2022-04-11
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影响因子：
--
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中科院分区：
文献类型：
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人类α疱疹病毒单纯疱疹病毒（HSV-1）和水痘带状疱疹病毒（VZV）在各种颅神经节中建立潜伏期，并经常因应激相关的免疫系统失调而重新激活。爱泼斯坦·巴尔病毒 (EBV)、VZV、HSV-1 和巨细胞病毒 (CMV) 的重新激活在太空飞行期间通常无症状，但活/传染性病毒已被回收，且脱落率随着任务持续时间而增加。因此，被分配执行长期任务（>180 天）的宇航员患临床疾病的风险可能会增加。在此，我们首次报告一例在长期太空飞行期间发生的 HSV-1 皮疹（皮炎）病例。宇航员在飞行期间报告了持续性皮炎，在机上接受了口服抗组胺药和外用/口服类固醇的治疗。在任务前 6 个月的唾液样本中未检测到 HSV-1 DNA，但在飞行第 82 天，唾液和皮疹拭子均分别检测到 4.8 拷贝/ng DNA 和 5.3 × 104 拷贝/ng DNA。任务后唾液样本仍然具有高感染性 HSV-1 载量（1.67 × 107 拷贝/ng DNA）。皮疹和唾液样本中的 HSV-1 具有 99.9% 的基因型同源性。本病例还提供了其他生理监测，包括应激生物标志物（皮质醇、脱氢表雄酮 (DHEA) 和唾液淀粉酶）、免疫标志物（适应性调节和炎症血浆细胞因子）和生化特征标志物，包括维生素/矿物质状态和骨代谢。这些数据强调了航天期间 HSV-1 的非典型表现，并强调了在飞行中皮炎临床评估期间进行病毒筛查以确定病毒病因并指导治疗的重要性。
Human alpha herpesviruses herpes simplex virus (HSV-1) and varicella zoster virus (VZV) establish latency in various cranial nerve ganglia and often reactivate in response to stress-associated immune system dysregulation. Reactivation of Epstein Barr virus (EBV), VZV, HSV-1, and cytomegalovirus (CMV) is typically asymptomatic during spaceflight, though live/infectious virus has been recovered and the shedding rate increases with mission duration. The risk of clinical disease, therefore, may increase for astronauts assigned to extended missions (>180 days). Here, we report, for the first time, a case of HSV-1 skin rash (dermatitis) occurring during long-duration spaceflight. The astronaut reported persistent dermatitis during flight, which was treated onboard with oral antihistamines and topical/oral steroids. No HSV-1 DNA was detected in 6-month pre-mission saliva samples, but on flight day 82, a saliva and rash swab both yielded 4.8 copies/ng DNA and 5.3 × 104 copies/ng DNA, respectively. Post-mission saliva samples continued to have a high infectious HSV-1 load (1.67 × 107 copies/ng DNA). HSV-1 from both rash and saliva samples had 99.9% genotype homology. Additional physiological monitoring, including stress biomarkers (cortisol, dehydroepiandrosterone (DHEA), and salivary amylase), immune markers (adaptive regulatory and inflammatory plasma cytokines), and biochemical profile markers, including vitamin/mineral status and bone metabolism, are also presented for this case. These data highlight an atypical presentation of HSV-1 during spaceflight and underscore the importance of viral screening during clinical evaluations of in-flight dermatitis to determine viral etiology and guide treatment.
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影响因子：
10.7
作者：
Depledge DP;Kundu S;Jensen NJ;Gray ER;Jones M;Steinberg S;Gershon A;Kinchington PR;Schmid DS;Balloux F;Nichols RA;Breuer J
通讯作者：
Breuer J
影响因子：
15.1
作者：
Mehta, S. K.;Laudenslager, M. L.;Pierson, D. L.
通讯作者：
Pierson, D. L.
DOI：
10.1016/s0027-5107(99)00133-5
发表时间：
1999-12-06
影响因子：
2.3
作者：
Horneck, G
通讯作者：
Horneck, G
影响因子：
1.2
作者：
Cingolani, Pablo;Platts, Adrian;Ruden, Douglas M.
通讯作者：
Ruden, Douglas M.
影响因子：
5.4
作者：
Johnston, Christine;Zhu, Jia;Corey, Lawrence
通讯作者：
Corey, Lawrence