Association of Vitamin D Status with SARS-CoV-2 Infection or COVID-19 Severity: A Systematic Review and Meta-analysis.
Association of Vitamin D Status with SARS-CoV-2 Infection or COVID-19 Severity: A Systematic Review and Meta-analysis.
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DOI：
10.1093/advances/nmab012
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发表时间：
2021-10-01
期刊：
影响因子：
--
通讯作者：
Babajafari S
中科院分区：
文献类型：
--
作者：
Kazemi A;Mohammadi V;Aghababaee SK;Golzarand M;Clark CCT;Babajafari S
本系统综述旨在总结和澄清 25-羟基维生素-D [25(OH)D] 浓度与 2019 年冠状病毒病 (COVID-19) 风险和结果之间关联的证据。检索截至 2020 年 11 月 26 日的 PubMed、Scopus、Web of Science 数据库和 Google Scholar。所有调查 25(OH)D 与严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染和 COVID-19 严重程度之间关系的回顾性和前瞻性队列研究、横断面研究、病例对照研究和随机对照试验研究均纳入其中。当前的系统评价纳入了 39 项研究。在针对混杂因素进行调整（OR：1.77；95% CI：1.24、2.53；I2：44.2%）和未调整（OR：1.75；95% CI：1.44、2.13；I2：33.0%）的研究中，维生素 D 缺乏 (VDD) 组感染 SARS-CoV-2 的风险较高。十五项研究评估了 VDD 与综合严重程度之间的关联。在针对混杂因素进行调整（OR：2.57；95% CI：1.65、4.01；I2 = 0.0%）和未调整（OR：10.61；95% CI：2.07、54.23；I2 = 90.8%）的研究中，VDD 组的严重程度更高。对粗 OR 的研究（OR：2.62；95% CI：1.13、6.05；I2：47.9%）和使用 Cox 生存法的调整研究（HR：7.67；95% CI：3.92、15.03；I2：0.0%）的分析表明 VDD 与死亡率存在显着相关性，而在使用逻辑回归的调整研究中，没有观察到相关性（OR： 1.05；95% CI：0.63，1.75；I2：76.6%）。研究 VDD 与重症监护病房 (ICU) 入院、肺部并发症、住院治疗和炎症之间关系的研究结果不一致。总之，尽管研究方法和统计方法各异，但大多数研究表明 25(OH)D 与 SARS-CoV-2 感染、COVID-19 综合严重程度和死亡率之间存在显着关系。关于感染，由于研究固有的局限性，在解释结果时应谨慎。对于入住ICU、炎症、住院和肺部受累，目前证据不一致且不充分。
This systematic review was conducted to summarize and clarify the evidence on the association between 25-hydroxyvitamin-D [25(OH)D] concentrations and coronavirus disease 2019 (COVID-19) risk and outcomes. PubMed, Scopus, and Web of Science databases and Google Scholar were searched up to 26 November 2020. All retrospective and prospective cohort, cross-sectional, case-control, and randomized controlled trial studies that investigated the relation between 25(OH)D and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19 severity were included. Thirty-nine studies were included in the current systematic review. In studies that were adjusted (OR: 1.77; 95% CI: 1.24, 2.53; I2: 44.2%) and nonadjusted for confounders (OR: 1.75; 95% CI: 1.44, 2.13; I2: 33.0%) there was a higher risk of SARS-CoV-2 infection in the vitamin D deficiency (VDD) group. Fifteen studies evaluated associations between VDD and composite severity. In the studies that were adjusted (OR: 2.57; 95% CI: 1.65, 4.01; I2 = 0.0%) and nonadjusted for confounders (OR: 10.61; 95% CI: 2.07, 54.23; I2 = 90.8%) there was a higher severity in the VDD group. Analysis of studies with crude OR (OR: 2.62; 95% CI: 1.13, 6.05; I2: 47.9%), and adjusted studies that used the Cox survival method (HR: 7.67; 95% CI: 3.92, 15.03; I2: 0.0%) indicated a significant association of VDD with mortality, while in adjusted studies that used logistic regression, no relation was observed (OR: 1.05; 95% CI: 0.63, 1.75; I2: 76.6%). The results of studies that examined relations between VDD and intensive care unit (ICU) admission, pulmonary complications, hospitalization, and inflammation were inconsistent. In conclusion, although studies were heterogeneous in methodological and statistical approach, most of them indicated a significant relation between 25(OH)D and SARS-CoV-2 infection, COVID-19 composite severity, and mortality. With regard to infection, caution should be taken in interpreting the results, due to inherent study limitations. For ICU admission, inflammation, hospitalization, and pulmonary involvement, the evidence is currently inconsistent and insufficient.
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DOI：
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发表时间：
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期刊：
Cureus
影响因子：
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发表时间：
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期刊：
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影响因子：
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