The impacts of delivery mode on infant's oral microflora.
The impacts of delivery mode on infant's oral microflora.
复制标题
DOI：
10.1038/s41598-018-30397-7
复制
发表时间：
2018-08-09
影响因子：
4.6
通讯作者：
Zhu Y
中科院分区：
文献类型：
--
作者：
Li H;Wang J;Wu L;Luo J;Liang X;Xiao B;Zhu Y
本研究调查了不同分娩方式对健康新生儿产后即刻口腔菌群的影响，并为医疗程序引起的微生物定植破坏提供了证据。18名剖宫产婴儿和74名阴道分娩婴儿被纳入研究。对出生后立即收集的口腔样本进行16S细菌rRNA的高通量测序。所有数据均采用生物信息学方法进行分析。本研究结果显示，剖宫产新生儿口腔细菌分布与阴道分娩新生儿不同。阴道组中以乳杆菌属、普雷沃菌属和加德纳菌属最多，而剖腹产组中以彼得单胞菌属、拟杆菌属、脱硫弧菌属、假单胞菌属、葡萄球菌属、微芽孢杆菌属、VadinCA02和双歧杆菌属最多。此外，从27名阴道分娩的婴儿中分离出的细菌没有聚集到阴道组中。她们中的大多数人在产房里呆了24小时以上，这导致了反复的绝育手术。我们推测，在这些病例中，重复绝育可能会影响口腔微生物菌群。总之，本研究表明，不同的分娩方式影响健康婴儿的口腔微生物区系。此外，临床上应注意外阴反复消毒可能阻碍阴道细菌定植。
This study investigated the effects of different delivery modes on oral microflora in healthy newborns immediately post-partum, and provided evidence for microbial colonization disruption induced by medical procedures. Eighteen infants delivered by cesarean section and 74 by vaginal delivery were included in the study. High-throughput sequencing of 16S bacterial rRNA was performed on oral samples collected immediately after birth. All data were analyzed using bioinformatics approaches. Our results indicated that different oral bacteria were found between infants delivered by cesarean section compared to vaginal delivery group. Lactobacillus, Prevotella and Gardnerella were the most abundant genera in the vaginal group, while Petrimonas, Bacteroides, Desulfovibrio, Pseudomonas, Staphylococcus, Tepidmicrobium, VadinCA02, and Bifidobacterium were dominant bacteria in the cesarean section (C-section) group. Furthermore, bacteria isolated from 27 vaginally-delivered infants were not clustered into the vaginal group. Most of them spent more than 24 hours in the delivery room and this led to repeated sterilization procedures. We hypothesized that repeated sterilization might have influenced oral microflora in those cases. To conclude, this study suggested that different modes of birth delivery affect oral microflora in healthy infants. In addition, attention shall be paid to the clinical practice of repeated sterilization of the vulva that possibly obstructs the colonization of vaginal bacterial.
登录
查看更多内容
影响因子：
3.7
作者：
Hong PY;Lee BW;Aw M;Shek LP;Yap GC;Chua KY;Liu WT
通讯作者：
Liu WT
影响因子：
14.9
作者：
Pruesse E;Quast C;Knittel K;Fuchs BM;Ludwig W;Peplies J;Glöckner FO
通讯作者：
Glöckner FO
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob
影响因子：
168.9
作者：
Lumbiganon, Pisake;Laopaiboon, Malinee;Villar, Jose
通讯作者：
Villar, Jose
影响因子：
4.3
作者：
White JR;Nagarajan N;Pop M
通讯作者：
Pop M