Effects of Infant Pneumococcal Conjugate Vaccination on Serotype Distribution in Invasive Pneumococcal Disease among Children and Adults in Germany.
Effects of Infant Pneumococcal Conjugate Vaccination on Serotype Distribution in Invasive Pneumococcal Disease among Children and Adults in Germany.
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DOI：
10.1371/journal.pone.0131494
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Imöhl M
中科院分区：
文献类型：
--
作者：
van der Linden M;Falkenhorst G;Perniciaro S;Imöhl M
本研究描述了2006年引入的普及婴儿肺炎球菌结合疫苗对德国儿童和成人侵袭性肺炎球菌病（IPD）的影响，重点是接种疫苗和未接种疫苗年龄组的血清型分布动态。在22年的时间里（1992-2014年），来自德国各地的微生物诊断实验室一直在自愿的基础上将IPD病例的分离株送到德国国家链球菌参考中心。使用Neufeld Quellung方法对肺炎链球菌分离株进行血清分型。在<16岁的儿童中，来自IPD病例的分离株中PCV 7血清型的比例从接种前（1997-2006）的61.8%下降到接种早期（2007-2010; p = 1.30E-72）的23.5%，并在接种后期（2010-2014; p = 4.59E-25）进一步下降到5.2%。在<2岁、2-4岁和5-15岁的不同年龄组中也看到了类似的减少。在成年人中，PCV 7血清型比例从接种前阶段（1992-2006年）的43.4%降至接种早期阶段的24.7%（p = 3.78 E-88）和接种后期阶段的8.2%（p = 5.97 E-161）。在儿童和成人中，非PCV 7血清型1、3、7 F和19 A在接种早期显著增加。在2010年从PCV 7转为PVC 10/PCV 13用于婴儿疫苗接种后，血清型1、6A和7 F显著减少。与2010-2011年相比，仅在2013-2014年观察到血清型19 A减少（儿童p = 4.16E-04，成人p = 6.98E-06）。在成人中，血清型3在疫苗接种早期强烈增加（p = 4.44E-15），但在疫苗接种后期保持恒定比例。在整个疫苗接种期间，非PCV 13疫苗血清型的比例有所增加，其中儿童血清型10A、12 F、23 B、24 F和38的增加最为显着，成人血清型6C、12 F、15 A、22 F和23 B的增加。在德国，8年的儿童肺炎球菌结合疫苗接种对接种目标人群以及年龄较大的儿童和成人的肺炎球菌群体产生了强烈的影响。
This study describes the effects of the introduction of universal infant pneumococcal conjugate vaccination in 2006 on invasive pneumococcal disease (IPD) among children and adults in Germany with a focus on the dynamics of serotype distribution in vaccinated and non-vaccinated age groups. Over a period of 22 years (1992–2014), microbiological diagnostic laboratories from all over Germany have been sending isolates of IPD cases to the German National Reference Center for Streptococci on a voluntary basis. Streptococcus pneumoniae isolates were serotyped using Neufeld’s Quellung method. Among children <16 years, the proportion of PCV7 serotypes among isolates from IPD cases decreased from 61.8% before vaccination (1997–2006) to 23.5% in the early vaccination period (2007–2010; p = 1.30E-72) and sank further to 5.2% in the late vaccination period (2010–2014; p = 4.59E-25). Similar reductions were seen for the separate age groups <2 years, 2-4 years and 5-15 years. Among adults, the proportion of PCV7 serotypes decreased from 43.4% in the pre-vaccination period (1992–2006) to 24.7% (p = 3.78E-88) in the early vaccination period and 8.2% (p = 5.97E-161) in the late vaccination period. Both among children and among adults, the non-PCV7 serotypes 1, 3, 7F and 19A significantly increased in the early vaccination period. After the switch from PCV7 to PVC10/PCV13 for infant vaccination in 2010, serotypes 1, 6A and 7F significantly decreased. A decrease in serotype 19A was only observed in 2013–2014, as compared to 2010–2011 (children p = 4.16E-04, adults p = 6.98E-06). Among adults, serotype 3, which strongly increased in the early vaccination period (p = 4.44E-15), remained at a constant proportion in the late vaccination period. The proportion of non-PCV13 vaccine serotypes increased over the whole vaccination period, with serotypes 10A, 12F, 23B, 24F and 38 most significantly increasing among children and serotypes 6C, 12F, 15A, 22F and 23B increasing among adults. Eight years of childhood pneumococcal conjugate vaccination have had a strong effect on the pneumococcal population in Germany, both among the target group for vaccination as well as among older children and adults.
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影响因子：
3.7
作者：
Camilli R;Spencer BL;Moschioni M;Pinto V;Berti F;Nahm MH;Pantosti A
通讯作者：
Pantosti A
影响因子：
15.8
作者：
Feikin, Daniel R.;Kagucia, Eunice W.;Moore, Matthew R.
通讯作者：
Moore, Matthew R.
影响因子：
5.5
作者：
Rueckinger, Simon;van der Linden, Mark;von Kries, Rildiger
通讯作者：
von Kries, Rildiger
影响因子：
11.8
作者：
Harboe, Zitta Barrella;Dalby, Tine;Valentiner-Branth, Palle
通讯作者：
Valentiner-Branth, Palle
影响因子：
3.6
作者：
Kaplan, Sheldon L.;Barson, William J.;Mason, Edward O., Jr.
通讯作者：
Mason, Edward O., Jr.