Hemostatic profiles in dogs with sudden acquired retinal degeneration syndrome.
Hemostatic profiles in dogs with sudden acquired retinal degeneration syndrome.
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DOI：
10.1111/jvim.16710
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发表时间：
2023-05
影响因子：
2.6
通讯作者：
中科院分区：
文献类型：
--
作者：
突发性获得性视网膜变性综合征（SARDS）是犬不可逆性失明的常见原因。它在临床上与皮质醇增多症相似，后者可能与高凝状态有关。高凝状态在SARDS犬中的作用尚不清楚。确定SARDS犬的止血特征。前瞻性初步研究：有SARDS病史的犬（n = 12）。前瞻性病例对照研究：近期发生SARDS的犬（n = 7）和年龄、品种和性别匹配的对照犬（n = 7）。前瞻性初步研究：我们进行了血栓弹力图（TEG）。前瞻性病例对照研究：对犬进行CBC、血清生化、尿分析、TEG、纤维蛋白原浓度、抗凝血酶活性、D-二聚体、凝血酶-抗凝血酶复合物和光学血小板聚集测定。前瞻性初步研究：9/12只有SARDS病史的犬出现高凝状态，TEG G值升高，2/3只出现高纤维蛋白原血症。病例对照研究：根据TEG G值，所有SARDS犬和5/7只对照犬均为高凝状态。与对照组相比，SARDS犬的G值（中位数，12.7 kdynes/s;范围，11.2 - 25.4; P = 0.04）和血浆纤维蛋白原浓度（中位数，463 mg/dL;范围，391 - 680; P <0.001）显著较高。高凝状态在SARDS犬和对照犬中均很常见，但SARDS犬在TEG时的高凝状态明显更强。高凝状态在SARDS发病机制中的作用仍有待确定。
Sudden acquired retinal degeneration syndrome (SARDS) is a common cause of irreversible blindness in dogs. It bears clinical resemblance to hypercortisolism, which can be associated with hypercoagulability. The role of hypercoagulability in dogs with SARDS is unknown. Determine hemostatic profiles in dogs with SARDS. Prospective pilot study: Dogs with a history of SARDS (n = 12). Prospective case‐control study: Dogs with recent onset of SARDS (n = 7) and age‐, breed‐, and sex‐matched controls (n = 7). Prospective pilot study: We performed thromboelastography (TEG). Prospective case‐control study: Dogs had CBC, serum biochemistry, urinalysis, TEG, fibrinogen concentration, antithrombin activity, D‐dimers, thrombin‐antithrombin complexes, and optical platelet aggregometry performed. Prospective pilot study: 9/12 dogs with a history of SARDS were hypercoagulable with increased TEG G value and 2/3 had hyperfibrinogenemia. Case‐control study: All dogs with SARDS and 5/7 controls were hypercoagulable based on TEG G value. Dogs with SARDS had significantly higher G values (median, 12.7 kdynes/s; range, 11.2‐25.4; P = .04) and plasma fibrinogen concentration (median, 463 mg/dL; range, 391‐680; P < .001) compared to controls. Hypercoagulability was common in both dogs with SARDS and controls, but dogs with SARDS were significantly more hypercoagulable on TEG. The role of hypercoagulability in the pathogenesis of SARDS remains to be determined.
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影响因子：
4.6
作者：
Brinks J;van Haalen FM;van Rijssen TJ;Biermasz NR;Meijer OC;Pereira AM;Boon CJF;van Dijk EHC
通讯作者：
van Dijk EHC
影响因子：
1.4
作者：
Ekesten, Bjorn;Komaromy, Andras M.;Narfstroem, Kristina
通讯作者：
Narfstroem, Kristina
影响因子：
2.2
作者：
Kol, A.;Nelson, R. W.;Borjesson, D. L.
通讯作者：
Borjesson, D. L.
影响因子：
2.6
作者：
Lennon, E. M.;Hanel, R. M.;Vaden, S. L.
通讯作者：
Vaden, S. L.
影响因子：
1.7
作者：
Limon, Utku;Bozkurt, Erdinc;Akcay, Sezgin
通讯作者：
Akcay, Sezgin