Effects of hyperbaric oxygen on metabolic capacity of the skeletal muscle in type 2 diabetic rats with obesity.
Effects of hyperbaric oxygen on metabolic capacity of the skeletal muscle in type 2 diabetic rats with obesity.
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DOI：
10.1100/2012/637978
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发表时间：
2012
影响因子：
--
通讯作者：
Fujino H
中科院分区：
文献类型：
--
作者：
Fujita N;Nagatomo F;Murakami S;Kondo H;Ishihara A;Fujino H
我们研究了高压氧是否能增强 2 型糖尿病肥胖大鼠骨骼肌的氧化代谢能力并减轻脂肪细胞肥大。五周大的雄性大冢长埃文斯德岛脂肪（OLETF）和长埃文斯德岛大冢（LETO）大鼠分别用作糖尿病动物和非糖尿病对照，并分配至对照组和高压氧组。高压氧组动物每天暴露在1.25大气压、36%氧气浓度下3小时。 OLETF大鼠27周龄时的血糖水平显着高于LETO大鼠，但暴露于高压氧的OLETF大鼠的升高受到抑制。在 OLETF 大鼠中观察到骨骼肌中从慢到快的纤维转变，但在暴露于高压氧的 OLETF 大鼠中这种转变受到抑制。此外，高压氧还增加了肌纤维的氧化酶活性。 OLETF大鼠的脂肪细胞大小大于LETO大鼠，但暴露于高压氧的OLETF大鼠中未观察到肥大的脂肪细胞。高压氧增强骨骼肌中的葡萄糖和脂质代谢，表明高压氧可以防止肥胖糖尿病大鼠的葡萄糖升高和脂肪细胞肥大。
We investigated whether hyperbaric oxygen enhances the oxidative metabolic capacity of the skeletal muscle and attenuates adipocyte hypertrophy in type 2 diabetic rats with obesity. Five-week-old male Otsuka Long-Evans Tokushima fatty (OLETF) and Long-Evans Tokushima Otsuka (LETO) rats were used as diabetic animals and nondiabetic controls, respectively, and assigned to control and hyperbaric oxygen groups. Animals in the hyperbaric oxygen group were exposed to an atmospheric pressure of 1.25 with an oxygen concentration of 36% for 3 h daily. The glucose level at 27 weeks of age was significantly higher in OLETF rats than in LETO rats, but the elevation was inhibited in OLETF rats exposed to hyperbaric oxygen. The slow-to-fast fiber transition in the skeletal muscle was observed in OLETF rats, but the shift was inhibited in OLETF rats exposed to hyperbaric oxygen. Additionally, the oxidative enzyme activity of muscle fibers was increased by hyperbaric oxygen. The adipocyte size was larger in OLETF rats than in LETO rats, but hypertrophied adipocytes were not observed in OLETF rats exposed to hyperbaric oxygen. Hyperbaric oxygen enhances glucose and lipid metabolism in the skeletal muscle, indicating that hyperbaric oxygen can prevent elevation of glucose and adipocyte hypertrophy in diabetic rats with obesity.
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影响因子：
2.4
作者：
Nagatomo F;Fujino H;Kondo H;Gu N;Takeda I;Ishioka N;Tsuda K;Ishihara A
通讯作者：
Ishihara A
影响因子：
7.7
作者：
Toda C;Shiuchi T;Lee S;Yamato-Esaki M;Fujino Y;Suzuki A;Okamoto S;Minokoshi Y
通讯作者：
Minokoshi Y
影响因子：
5.4
作者：
Gu, Ning;Nagatomo, Fumiko;Ishihara, Akihiko
通讯作者：
Ishihara, Akihiko
DOI：
10.1152/ajpendo.00500.2006
发表时间：
2007-07-01
影响因子：
5.1
作者：
Noland, Robert C.;Thyfault, John P.;Lust, Robert M.
通讯作者：
Lust, Robert M.
影响因子：
2.5
作者：
Bikman BT;Woodlief TL;Noland RC;Britton SL;Koch LG;Lust RM;Dohm GL;Cortright RN
通讯作者：
Cortright RN