A bacterial interference strategy for prevention of UTI in persons practicing intermittent catheterization.
A bacterial interference strategy for prevention of UTI in persons practicing intermittent catheterization.
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DOI：
10.1038/sc.2008.166
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发表时间：
2009-07
期刊：
影响因子：
2.2
通讯作者：
Trautner, B. W.
中科院分区：
文献类型：
--
作者：
Prasad, A.;Cevallos, M. E.;Riosa, S.;Darouiche, R. O.;Trautner, B. W.
非随机试点试验确定在脊髓损伤 (SCI) 患者中进行间歇性导尿计划 (ICP) 时，大肠杆菌 83972 涂层导尿管是否能够 (1) 实现这种良性微生物在膀胱定植，以及 (2) 降低有症状的尿路感染 (UTI) 的发生率。退伍军人事务部医院的 SCI 门诊（美国） 参与者患有继发于 SCI 的神经源性膀胱，正在练习 ICP，经历过至少 1 次 UTI，并在过去一年内记录有菌尿。所有受试者均接受了预先接种了大肠杆菌 83972 的导尿管。将导尿管留在原处 3 天，然后取出。持续 28 天，每周对受试者进行尿培养和电话随访，然后每月进行一次，直到大肠杆菌 83972 从尿液中消失。结果指标为 (1) 膀胱定植成功率，定义为拔除导管后 3 天以上在尿液培养物中检测到大肠杆菌 83972（≥102 cfu/ml），以及 (2) 大肠杆菌 83972 定植期间出现症状性 UTI 的发生率。 13 名受试者接受了 19 次研究导管插入。拔除导管后 8 名受试者 (62%) 成功定植超过 3 天。在这 8 名受试者中，定植期间的 UTI 率为每患者年 0.77 例，而入组前的 UTI 率为每患者年 2.27 例。大肠杆菌 83972 涂层导尿管是实现 ICP 患者膀胱定植的可行方法，具有潜在的保护性菌株。
Non-randomized pilot trial Determine whether Escherichia coli 83972-coated urinary catheters in persons with spinal cord injury (SCI) practicing an intermittent catheterization program (ICP) could (1) achieve bladder colonization with this benign organism, and (2) decrease the rate of symptomatic urinary tract infection (UTI). Outpatient SCI clinic in a Veterans Affairs hospital (USA) Participants had neurogenic bladders secondary to SCI, were practicing ICP, had experienced at least 1 UTI, and had documented bacteruria within the past year. All subjects received a urinary catheter that had been pre-inoculated with E. coli 83972. The catheter was left in place for 3 days then removed. Subjects were followed with urine cultures and telephone calls weekly for 28 days and then monthly until E. coli 83972 was lost from the urine. Outcome measures were (1) the rate of successful bladder colonization, defined as the detection (≥102 cfu/ml) of E. coli 83972 in urine cultures for > 3 days after catheter removal and (2) the rate of symptomatic UTI while colonized with E. coli 83972. Thirteen subjects underwent 19 insertions of study catheters. Eight subjects (62%) became successfully colonized for > 3 days after catheter removal. In these 8 subjects, the rate of UTI while colonized was 0.77 per patient-year, in comparison to the rate of 2.27 UTI per patient-year prior to enrollment. E. coli 83972-coated urinary catheters are a viable means to achieve bladder colonization with this potentially protective strain in persons practicing ICP.
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影响因子：
2.1
作者：
Trautner, BW;Hull, RA;Darouiche, RO
通讯作者：
Darouiche, RO
影响因子：
2.1
作者：
Darouiche, RO;Donovan, WH;Hull, RA
通讯作者：
Hull, RA
影响因子：
6.4
作者：
WARREN, JW;TENNEY, JH;ANTHONY, WC
通讯作者：
ANTHONY, WC
影响因子：
11.8
作者：
Darouiche, RO
通讯作者：
Darouiche, RO
影响因子：
4.5
作者：
Trautner, Barbara W.;Hull, Richard A.;Darouiche, Rabih O.
通讯作者：
Darouiche, Rabih O.