Spatial representations of odorants in olfactory bulbs of rats and mice: similarities and differences in chemotopic organization.
Spatial representations of odorants in olfactory bulbs of rats and mice: similarities and differences in chemotopic organization.
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在大鼠和小鼠的嗅球中，气味的空间表示：趋化组织中的相似性和差异。
DOI：
10.1002/cne.22046
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发表时间：
2009-06-20
期刊：
影响因子：
--
通讯作者：
Leon M
中科院分区：
文献类型：
--
作者：
Johnson BA;Xu Z;Ali SS;Leon M
在以前的研究中，我们映射肾小球层2-脱氧葡萄糖摄取引起的数百个系统相关的和化学上不同的气味在大鼠嗅球。为了确定在这些研究中揭示的化学位置组织的哪些原则可能更基本，哪些可能更具有物种典型性，我们现在已经描述了小鼠对30种这些气味剂的反应模式。我们发现，只有少数气味诱发他们的多个焦点的峰值活动在完全相同的位置在两个物种。在小鼠中，就像在大鼠中一样，具有相同分子特征的气味会诱发重叠的模式，但特征反应域的位置在大鼠和小鼠中往往不同。在大鼠中，增加碳数内的一系列同源的脂肪族气味通常与吻和腹侧的进展的活动范围内响应气味官能团和/或烃骨架。这种化学位置的进展在小鼠中并不明显，相反，在由单个亚甲基基团不同的气味剂的域内，活化的肾小球显示出更突然的差异。尽管存在差异，整体摄取模式之间的定量关系表现出类似的组织气味化学的两个物种，可能是由于部分重叠的峰域和更广泛的重叠在大，低活性的地区，大鼠和小鼠。我们的结论是，集群共享气味特征的反应可能是气味编码的一般策略，但高活性域的具体位置可能是独特的物种。
In previous studies, we mapped glomerular layer 2-deoxyglucose uptake evoked by hundreds of both systematically related and chemically distinct odorants in rat olfactory bulbs. To determine which principles of chemotopic organization revealed in these studies may be more fundamental and which may be more species-typical, we now have characterized patterns of responses to 30 of these odorants in mice. We found that only a few odorants evoked their multiple foci of peak activity in exactly the same locations in the two species. In mice, as in rats, odorants that shared molecular features evoked overlapping patterns, but the locations of the feature-responsive domains often differed in rats and mice. In rats, increasing carbon number within a homologous series of aliphatic odorants is generally associated with rostral and ventral progressions of activity within domains responding to odorant functional group and/or hydrocarbon backbone. Such chemotopic progressions were not obvious in mice, which instead showed more abrupt differences in activated glomeruli within the domains for odorants differing by a single methylene group. Despite the differences, quantitative relationships between overall uptake patterns exhibited a similar organization with respect to odorant chemistry for the two species, probably due to partial overlaps of peak domains and more extensive overlaps in large, low-activity areas for rats and mice. We conclude that clustering responses to shared odorant features may be a general strategy for odor coding, but that the specific locations of high-activity domains may be unique to a species.
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DOI：
10.1073/pnas.90.8.3329
发表时间：
1993-04-15
影响因子：
11.1
作者：
GUTHRIE, KM;ANDERSON, AJ;GALL, C
通讯作者：
GALL, C
影响因子：
2.9
作者：
JOURDAN, F;DUVEAU, A;HOLLEY, A
通讯作者：
HOLLEY, A
影响因子：
3.3
作者：
Kida, I;Xu, FQ;Hyder, F
通讯作者：
Hyder, F
影响因子：
2.5
作者：
Johnson, BA;Ho, SL;Leon, M
通讯作者：
Leon, M
影响因子：
64.8
作者：
Kobayakawa, Ko;Kobayakawa, Reiko;Sakano, Hitoshi
通讯作者：
Sakano, Hitoshi