Tinned fruit consumption and mortality in three prospective cohorts.
Tinned fruit consumption and mortality in three prospective cohorts.
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DOI：
10.1371/journal.pone.0117796
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Wareham NJ
中科院分区：
文献类型：
--
作者：
Aasheim ET;Sharp SJ;Appleby PN;Shipley MJ;Lentjes MA;Khaw KT;Brunner E;Key TJ;Wareham NJ
促进健康的饮食建议包括新鲜、冷冻和罐装水果，但很少有研究调查罐装水果对健康的好处。因此，我们研究了罐头水果消费与死亡率之间的关系。我们对来自英国三个前瞻性队列的参与者进行了随访：来自欧洲癌症与营养前瞻性调查(EPIC)-诺福克队列（1993-2012）的22,421名参与者，来自EPIC-牛津队列（1993-2012）的52,625名参与者，以及来自白厅II队列（1991-2012）的7440名参与者，所有参与者在进入这些研究时都没有心脏病发作、中风或癌症史。我们在每个队列中使用Cox回归模型估计了罐装水果消费频率与全因死亡率（主要结局指标）之间的关联，并使用随机效应荟萃分析汇总了各队列的风险比。通过有效的食物频率问卷对罐头水果的消费进行评估，其中包括有关罐头水果的具体问题。在1,305,330人年的随访期间，发生了8857例死亡。在对生活方式因素和风险标记进行调整后，与每月食用罐头水果少于一次的参照组相比，全因死亡率的合并风险比（95%置信区间）为：每月1至3次的合计风险比为1.05(0.99,1.12)，每周1次的合计风险比为1.10(1.03,1.18)，每周2次以上的合计风险比为1.13（1.04,1.23）。死因特异性死亡率分析表明，食用罐头水果与心血管原因、非心血管原因、非癌症原因的死亡率有关。在一项对来自英国的三个前瞻性队列的汇总分析中，自我报告的20世纪90年代罐装水果消费量与长期随访期间的死亡率呈微弱但正相关。这些发现提出了一个问题，即促进罐头水果消费作为健康饮食的一部分的饮食建议的证据。
Dietary recommendations to promote health include fresh, frozen and tinned fruit, but few studies have examined the health benefits of tinned fruit. We therefore studied the association between tinned fruit consumption and mortality. We followed up participants from three prospective cohorts in the United Kingdom: 22,421 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohort (1993–2012), 52,625 participants from the EPIC-Oxford cohort (1993–2012), and 7440 participants from the Whitehall II cohort (1991–2012), all reporting no history of heart attack, stroke, or cancer when entering these studies. We estimated the association between frequency of tinned fruit consumption and all cause mortality (primary outcome measure) using Cox regression models within each cohort, and pooled hazard ratios across cohorts using random-effects meta-analysis. Tinned fruit consumption was assessed with validated food frequency questionnaires including specific questions about tinned fruit. During 1,305,330 person years of follow-up, 8857 deaths occurred. After adjustment for lifestyle factors and risk markers the pooled hazard ratios (95% confidence interval) of all cause mortality compared with the reference group of tinned fruit consumption less often than one serving per month were: 1.05 (0.99, 1.12) for one to three servings per month, 1.10 (1.03, 1.18) for one serving per week, and 1.13 (1.04, 1.23) for two or more servings per week. Analysis of cause-specific mortality showed that tinned fruit consumption was associated with mortality from cardiovascular causes and from non-cardiovascular, non-cancer causes. In a pooled analysis of three prospective cohorts from the United Kingdom self-reported tinned fruit consumption in the 1990s was weakly but positively associated with mortality during long-term follow-up. These findings raise questions about the evidence underlying dietary recommendations to promote tinned fruit consumption as part of a healthy diet.
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影响因子：
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作者：
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