Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota
Antibiotics may increase triazine herbicide exposure risk via disturbing gut microbiota
复制标题
抗生素可能通过扰乱肠道微生物群而增加三嗪除草剂暴露风险
DOI：
10.1186/s40168-018-0602-5
复制
发表时间：
2018-12
期刊：
影响因子：
15.5
通讯作者：
Zhou Zhiqiang
中科院分区：
文献类型：
--
作者：
Zhan Jing;Liang Yiran;Liu Donghui;Wang Peng;Zhou Zhiqiang
背景抗生素是世界范围内广泛使用的抗生素，农药是人类经常接触的一种外源性物质。抗生素对农药的相互影响很少被研究。我们的目的是研究抗生素对农药暴露风险的影响，以及抗生素改变的肠道微生物群是否会影响农药的生物利用度。此外，我们探讨了肠道微生物群的机制，影响农药的命运在host.ResultsThe口服生物利用度的三嗪除草剂显着增加，氨苄青霉素或抗生素鸡尾酒治疗的大鼠。肠道菌群的改变通过下调肝脏代谢酶基因表达和上调肠道吸收相关蛋白直接影响农药生物利用度的增加。肠道菌群的改变，可能会改变肝脏代谢酶基因表达和肠道吸收相关的蛋白质组是生物利用度增加的一个关键原因。这项研究揭示了抗生素对健康的潜在影响，并提醒人们在服用抗生素时考虑共同暴露的外源性物质。
BackgroundAntibiotics are commonly used worldwide, and pesticide is a kind of xenobiotic to which humans are frequently exposed. The interactive impact of antibiotics on pesticides has rarely been studied. We aim to investigate the effects of antibiotics on the pesticide exposure risk and whether gut microbiota altered by antibiotics has an influence on pesticide bioavailability. Furthermore, we explored the mechanisms of gut microbiota affecting the fate of pesticides in the host.ResultsThe oral bioavailability of triazine herbicides significantly increased in the rats treated with ampicillin or antibiotic cocktails. The antibiotic-altered gut microbiota directly influenced the increased pesticide bioavailability through downregulating hepatic metabolic enzyme gene expression and upregulating intestinal absorption-related proteins.ConclusionsAntibiotics could increase the pesticide bioavailability and thereby may increase the pesticide exposure risk. The antibiotic-altered gut microbiota that could alter the hepatic metabolic enzyme gene expression and intestinal absorption-related proteome was a critical cause of the increased bioavailability. This study revealed an undiscovered potential health impact of antibiotics and reminded people to consider the co-exposed xenobiotics when taking antibiotics.
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影响因子：
10.6
作者：
Bruce-Keller AJ;Salbaum JM;Luo M;Blanchard E 4th;Taylor CM;Welsh DA;Berthoud HR
通讯作者：
Berthoud HR
DOI：
10.3390/molecules23040795
发表时间：
2018-03-30
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Manyi-Loh C;Mamphweli S;Meyer E;Okoh A
通讯作者：
Okoh A
影响因子：
64.5
作者：
Maurice CF;Haiser HJ;Turnbaugh PJ
通讯作者：
Turnbaugh PJ
影响因子：
4.2
作者：
Barra Caracciolo, Anna;Fajardo, Carmen;Gibello, Alicia
通讯作者：
Gibello, Alicia
影响因子：
3.8
作者：
Park, Si Eun;Lim, Sa Rang;Bae, Jeehyeon
通讯作者：
Bae, Jeehyeon