Transcriptional regulation of innate lymphoid cells and T cells by aryl hydrocarbon receptor.
Transcriptional regulation of innate lymphoid cells and T cells by aryl hydrocarbon receptor.
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DOI：
10.3389/fimmu.2023.1056267
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发表时间：
2023
影响因子：
7.3
通讯作者：
Zhou, Liang
中科院分区：
文献类型：
--
作者：
Helm, Eric Y.;Zhou, Liang
关键词：
芳香烃受体（Ahr）是一种配体依赖性转录因子，通过细胞、饮食和微生物代谢产物以及环境毒素激活，促进免疫细胞环境感知。虽然在各种细胞类型中表达，但先天淋巴样细胞（ILC）及其适应性T细胞对应物中的Ahr调节其发育和功能的重要方面。与T细胞相反，ILC仅依赖于生殖系编码的受体进行活化，但通常与它们的T细胞对应物共享核心转录因子的表达并产生共享的效应分子。因此，转录调控的核心模块在ILC和T细胞之间既共享又分歧。在这篇综述中，我们重点介绍了Ahr对ILC和T细胞的转录调控的最新研究结果。此外，我们专注于阐明Ahr调节先天性和适应性淋巴细胞的共同和独特机制的见解。
The aryl hydrocarbon receptor (Ahr) is a ligand-dependent transcription factor and facilitates immune cell environmental sensing through its activation by cellular, dietary, and microbial metabolites, as well as environmental toxins. Although expressed in various cell types, Ahr in innate lymphoid cells (ILCs) and their adaptive T cell counterparts regulates essential aspects of their development and function. As opposed to T cells, ILCs exclusively rely on germ-line encoded receptors for activation, but often share expression of core transcription factors and produce shared effector molecules with their T cell counterparts. As such, core modules of transcriptional regulation are both shared and diverge between ILCs and T cells. In this review, we highlight the most recent findings regarding Ahr’s transcriptional regulation of both ILCs and T cells. Furthermore, we focus on insights elucidating the shared and distinct mechanisms by which Ahr regulates both innate and adaptive lymphocytes.
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影响因子：
30.5
作者：
通讯作者：
--
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DOI：
10.1016/j.jaci.2018.03.007
发表时间：
2019-01
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Cai T;Qiu J;Ji Y;Li W;Ding Z;Suo C;Chang J;Wang J;He R;Qian Y;Guo X;Zhou L;Sheng H;Shen L;Qiu J
通讯作者：
Qiu J
影响因子：
32.4
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Basu R;O'Quinn DB;Silberger DJ;Schoeb TR;Fouser L;Ouyang W;Hatton RD;Weaver CT
通讯作者：
Weaver CT
影响因子：
32.4
作者：
Diefenbach, Andreas;Colonna, Marco;Koyasu, Shigeo
通讯作者：
Koyasu, Shigeo
影响因子：
32.4
作者：
Guo, Xiaohuan;Qiu, Ju;Tu, Tony;Yang, Xuanming;Deng, Liufu;Anders, Robert A.;Zhou, Liang;Fu, Yang-Xin
通讯作者：
Fu, Yang-Xin