Influence of chronic administration of antidepressant drugs on mRNA for galanin, galanin receptors, and tyrosine hydroxylase in catecholaminergic and serotonergic cell-body regions in rat brain.
Influence of chronic administration of antidepressant drugs on mRNA for galanin, galanin receptors, and tyrosine hydroxylase in catecholaminergic and serotonergic cell-body regions in rat brain.
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DOI：
10.1016/j.npep.2012.01.001
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发表时间：
2012-04
期刊：
影响因子：
2.9
通讯作者：
Weiss, Jay M.
中科院分区：
文献类型：
--
作者：
Rovin, Molly L.;Boss-Williams, Katherine A.;Alisch, Reid S.;Ritchie, James C.;Weinshenker, David;West, Charles H. K.;Weiss, Jay M.
关键词：
蓝斑（LC）神经元的活性和与LC神经元中去甲肾上腺素（NE）共定位的肽丙氨酸（GAL）的释放与抑郁症有关，反过来也与抗抑郁作用有关。本研究检测了慢性给药（14天，通过皮下植入微型泵）抗抑郁药（AD）代表三种不同类别的药物（三环[去西帕明]，选择性血清素再摄取抑制剂[SSRI][帕罗西汀]和单胺氧化酶抑制剂[MAOI][苯肼]）对四个脑区- LC， A1/C1, A1/C1， LC中GAL， GAL受体（GalR1， R2和R3）和酪氨酸羟化酶（TH）， NE合成的限制性酶的mRNA的影响。大鼠背中缝（DRN）和腹侧被盖（VTA）。与先前的研究结果一致，慢性给药AD药物会降低LC神经元的活性，给药AD药物会降低LC神经元中GAL和TH的mRNA表达。LC神经元中GAL和TH mRNA高度相关。AD药物也降低了A1/C1和VTA中的GAL和TH mRNA，但作用小于LC。AD引起的GAL受体mRNA的最大变化是VTA区GalR2受体mRNA的减少。此外，GalR2和GalR3受体的mRNA在所有三个主要儿茶酚胺能脑区（LC， A1/C1和VTA）中显著（正）相关。相对于这三个大脑区域，DRN区域具有独特的作用，SSRI升高GAL mRNA， GalR1和GalR3的mRNA在该大脑区域高度相关。研究结果表明，长期服用AD药物可以产生有效的抗抑郁作用，导致可能参与抑郁和抗抑郁作用的大脑区域中GAL、GAL受体和TH mRNA的变化。
Activity of locus coeruleus (LC) neurons and release of the peptide galanin (GAL), which is colocalized with norepinephrine (NE) in LC neurons, has been implicated in depression and, conversely, in antidepressant action. The present study examined the influence of chronic administration (for 14 days, via subcutaneously-implanted minipump) of antidepressant (AD) drugs representing three different classes (tricyclic [desipramine], selective serotonin reuptake inhibitor [SSRI] [paroxetine], and monoamine oxidase inhibitor [MAOI] [phenelzine]) on mRNA for GAL, GAL receptors (GalR1, R2, and R3), and tyrosine hydroxylase (TH), the rate-limiting enzyme for NE synthesis, in four brain regions – LC, A1/C1, dorsal raphe (DRN), and ventral tegmentum (VTA) of rats. Consistent with previous findings that chronic administration of AD drugs decreases activity of LC neurons, administration of AD drugs reduced mRNA for both GAL and TH in LC neurons. GAL and TH mRNA in LC neurons was highly correlated. AD drugs also reduced GAL and TH mRNA in A1/C1 and VTA but effects were smaller than in LC. The largest change in mRNA for GAL receptors produced by AD administration was to decrease mRNA for GalR2 receptors in the VTA region. Also, mRNA for GalR2 and GalR3 receptors was significantly (positively) correlated in all three predominantly catecholaminergic brain regions (LC, A1/C1, and VTA). Relative to these three brain regions, unique effects were seen in the DRN region, with the SSRI elevating GAL mRNA and with mRNA for GalR1 and GalR3 being highly correlated in this brain region. The findings show that chronic administration of AD drugs, which produces effective antidepressant action, results in changes in mRNA for GAL, GAL receptors, and TH in brain regions that likely participate in depression and antidepressant effects.
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影响因子：
2.7
作者：
CARLI, M;ROBBINS, TW;EVERITT, BJ
通讯作者：
EVERITT, BJ
影响因子：
3.6
作者：
MUSEO, E;WISE, RA
通讯作者：
WISE, RA
影响因子：
3.3
作者：
Mitsukawa, K.;Lu, X.;Bartfai, T.
通讯作者：
Bartfai, T.
DOI：
10.1016/s0163-1047(84)90412-6
发表时间：
1984-01-01
期刊：
BEHAVIORAL AND NEURAL BIOLOGY
影响因子：
--
作者：
MOGENSON, GJ;NIELSEN, M
通讯作者：
NIELSEN, M
DOI：
10.1073/pnas.87.19.7522
发表时间：
1990-10-01
影响因子：
11.1
作者：
NESTLER, EJ;MCMAHON, A;DUMAN, RS
通讯作者：
DUMAN, RS