Population-based incidence of human metapneumovirus infection among hospitalized children.
Population-based incidence of human metapneumovirus infection among hospitalized children.
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DOI：
10.1086/652782
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发表时间：
2010-06-15
期刊：
影响因子：
--
通讯作者：
Crowe JE Jr
中科院分区：
文献类型：
--
作者：
Williams JV;Edwards KM;Weinberg GA;Griffin MR;Hall CB;Zhu Y;Szilagyi PG;Wang CK;Yang CF;Silva D;Ye D;Spaete RR;Crowe JE Jr
Background. Human metapneumovirus (HMPV) is a leading cause of acute respiratory illness (ARI) in children. Population-based incidence rates and comprehensive clinical characterizations of disease have not been established. Methods. We conducted population-based prospective surveillance for 2 years in 2 US counties of HMPV infection among children <5 years old who were hospitalized with ARI or fever. Nasal and throat specimens obtained with swabs were tested for HMPV by real-time reverse-transcription polymerase chain reaction and genotyped. Results. Forty-two (3.8%) of 1104 children tested positive for HMPV. The overall annual rate of HMPVassociated hospitalizations per 1000 children <5 years old was 1.2 (95% confidence interval [CI], 0.9–1.6). This rate was highest among infants 0–5 months old (4.9 per 1000 [95% CI, 2.9–7.2]), followed by children 6–11 months old (2.9 per 1000 [95% CI, 1.4–4.7]). The annual rate of hospitalization for HMPV infection was less than that for respiratory syncytial virus infection but similar to that for influenza and parainfluenza virus 3 infection in all age groups. The mean age of children hospitalized with HMPV infection was 6 months. Bronchiolitis, pneumonia, and asthma were the most common diagnoses among children with HMPV infection. All 4 HMPV subgroups were detected during both years at both sites. HPMV infection was most prominent from March through May. Conclusion. HMPV was detected in 3.8% of children hospitalized with ARI or fever, with a population incidence similar to that of influenza virus and parainfluenza virus 3.
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影响因子：
11.8
作者：
Mullins JA;Erdman DD;Weinberg GA;Edwards K;Hall CB;Walker FJ;Iwane M;Anderson LJ
通讯作者：
Anderson LJ
DOI：
10.1016/j.jaci.2008.10.007
发表时间：
2009-01
期刊：
The Journal of allergy and clinical immunology
影响因子：
--
作者：
Miller EK;Edwards KM;Weinberg GA;Iwane MK;Griffin MR;Hall CB;Zhu Y;Szilagyi PG;Morin LL;Heil LH;Lu X;Williams JV;New Vaccine Surveillance Network
通讯作者：
New Vaccine Surveillance Network
DOI：
10.1056/nejmoa0804877
发表时间：
2009-02-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hall CB;Weinberg GA;Iwane MK;Blumkin AK;Edwards KM;Staat MA;Auinger P;Griffin MR;Poehling KA;Erdman D;Grijalva CG;Zhu Y;Szilagyi P
通讯作者：
Szilagyi P
影响因子：
9.4
作者：
Maertzdorf, J;Wang, CK;Fouchier, RAM
通讯作者：
Fouchier, RAM
影响因子：
11.8
作者：
Boivin, Guy;De Serres, Gaston;Couture, Christian
通讯作者：
Couture, Christian