Human metapneumovirus infection among children hospitalized with acute respiratory illness.
Human metapneumovirus infection among children hospitalized with acute respiratory illness.
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DOI：
10.3201/eid1004.030555
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发表时间：
2004-04
影响因子：
11.8
通讯作者：
Anderson LJ
中科院分区：
文献类型：
--
作者：
Mullins JA;Erdman DD;Weinberg GA;Edwards K;Hall CB;Walker FJ;Iwane M;Anderson LJ
最近的研究表明，人类偏肺病毒 (HMPV) 感染与儿童呼吸道疾病的严重程度与呼吸道合胞病毒 (RSV) 感染相似。我们研究了 668 份储存的拭子样本（每次入院一份），这些样本是从一项针对美国两个城市住院儿童急性呼吸道疾病的基于人群的前瞻性研究中收集的。通过逆转录聚合酶链反应测定对样本进行了 HMPV、RSV、流感和副流感病毒检测。二十六人 (3.9%) HMPV 呈阳性； RSV 125 (18.7%)；副流感 1、2 或 3 型为 45 (6.7%)； 23 人（3.4%）患有流感。 HMPV 阳性儿童的年龄明显大于 RSV 阳性儿童。 HMPV 阳性儿童需要医疗重症监护，并以与 RSV 阳性儿童相似的频率接受补充氧气。在因呼吸道疾病住院的儿童中，HMPV 感染的发生率低于 RSV，但临床疾病严重程度与 RSV 感染相同。需要进一步研究以更好地表征 HMPV 感染及其临床效果。
Recent studies have associated human Metapneumovirus (HMPV) infection in children with respiratory disease of similar severity as respiratory syncytial virus (RSV) infection. We studied 668 banked swab specimens (one per admission) collected from a population-based, prospective study of acute respiratory illness among inpatient children from two U.S. cities. Specimens were tested for HMPV, RSV, influenza, and parainfluenza viruses by reverse transcription–polymerase chain reaction assays. Twenty-six (3.9%) were positive for HMPV; 125 (18.7%) for RSV; 45 (6.7%) for parainfluenza 1, 2, or 3; and 23 (3.4%) for influenza. HMPV-positive children were significantly older than RSV-positive children. HMPV-positive children required medical intensive care and received supplemental oxygen in similar frequencies to RSV-positive children. Among children hospitalized with respiratory illness, the incidence of HMPV infection was less than RSV, but clinical disease severity mirrored that of RSV infection. Further investigations to better characterize HMPV infection and its clinical effect are needed.
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影响因子：
82.9
作者：
van den Hoogen BG;de Jong JC;Groen J;Kuiken T;de Groot R;Fouchier RA;Osterhaus AD
通讯作者：
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