Sympathetic neural recruitment strategies following acute intermittent hypoxia in humans.
Sympathetic neural recruitment strategies following acute intermittent hypoxia in humans.
复制标题
人类急性间歇性缺氧后的交感神经募集策略。
DOI：
10.1152/ajpregu.00004.2020
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Limberg,JacquelineK
中科院分区：
文献类型：
--
作者：
Ott,ElizabethP;Jacob,DainW;Baker,SarahE;Holbein,WalterW;Scruggs,ZachariahM;Shoemaker,JKevin;Limberg,JacquelineK
我们研究了急性间歇性缺氧（IH）对交感神经放电模式的影响和颈动脉化学感受器的作用。我们假设暴露于急性IH会通过增加动作电位（AP）放电率和爆发内放电来增加肌肉交感神经活动（MSNA）。我们进一步假设，在急性化学感受器失活（高氧）过程中，放电模式的任何变化都会减弱。对17名健康成人（11名男性/6名女性; 31 ± 1岁）在实验性IH前和30分钟后的常氧休息期间进行了MSNA（显微神经造影术）评估。在IH之前和之后，参与者暴露于2分钟的100%氧气（高氧）。使用基于小波的方法从滤波的原始MSNA信号研究AP模式。与基线相比，IH后多单位MSNA爆发发生率（P< 0.01）、AP发生率（P= 0.01）和每次爆发的AP含量（P= 0.01）增加。IH后AP簇放电一次（P< 0.01）和一次以上（P= 0.03）的概率增加。基线或IH后高氧对多单位MSNA没有影响（P> 0.05）;然而，IH后高氧降低了特定AP簇每次放电超过一次的可能性（P< 0.01）。急性IH通过增加AP放电率和爆发内放电来增加MSNA。IH后爆发内放电增加的一部分可归因于颈动脉化学感受器。这些数据推进了人类急性IH后交感神经激活的机制理解。
We examined the effect of acute intermittent hypoxia (IH) on sympathetic neural firing patterns and the role of the carotid chemoreceptors. We hypothesized exposure to acute IH would increase muscle sympathetic nerve activity (MSNA) via an increase in action potential (AP) discharge rates and within-burst firing. We further hypothesized any change in discharge patterns would be attenuated during acute chemoreceptor deactivation (hyperoxia). MSNA (microneurography) was assessed in 17 healthy adults (11 male/6 female; 31 ± 1 yr) during normoxic rest before and after 30 min of experimental IH. Prior to and following IH, participants were exposed to 2 min of 100% oxygen (hyperoxia). AP patterns were studied from the filtered raw MSNA signal using wavelet-based methodology. Compared with baseline, multiunit MSNA burst incidence (P< 0.01), AP incidence (P= 0.01), and AP content per burst (P= 0.01) were increased following IH. There was an increase in the probability of a particular AP cluster firing once (P< 0.01) and more than once (P= 0.03) per burst following IH. There was no effect of hyperoxia on multiunit MSNA at baseline or following IH (P> 0.05); however, hyperoxia following IH attenuated the probability of particular AP clusters firing more than once per burst (P< 0.01). Acute IH increases MSNA by increasing AP discharge rates and within-burst firing. A portion of the increase in within-burst firing following IH can be attributed to the carotid chemoreceptors. These data advance the mechanistic understanding of sympathetic activation following acute IH in humans.
登录
查看更多内容
健康人动脉压力反射对交感神经放电模式贡献的药理学评估。
影响因子：
2.5
作者：
Limberg,JacquelineK;Ott,ElizabethP;Holbein,WalterW;Baker,SarahE;Curry,TimothyB;Nicholson,WayneT;Joyner,MichaelJ;Shoemaker,JKevin
通讯作者：
Shoemaker,JKevin
耐力训练减弱了间歇性缺氧时外周化学反射敏感性的增加。
DOI：
10.1152/ajpregu.00105.2016
发表时间：
2017
期刊：
American journal of physiology. Regulatory, integrative and comparative physiology
影响因子：
--
作者：
Miller,AmandaJ;Sauder,CharityL;Cauffman,AimeeE;Blaha,CherylA;Leuenberger,UrsA
通讯作者：
Leuenberger,UrsA
急性缺氧后交感神经爆发频率和幅度的差异调节
DOI：
--
发表时间：
2012
期刊：
American Journal of Physiology. Regulatory Integrative and Comparative Physiology
影响因子：
--
作者：
C. Steinback;J. Shoemaker
通讯作者：
J. Shoemaker
影响因子：
5.5
作者：
Stuckless, Troy J. R.;Vermeulen, Tyler D.;Foster, Glen E.
通讯作者：
Foster, Glen E.
DOI：
10.1152/ajpheart.00653.2007
发表时间：
2008-08-01
影响因子：
4.8
作者：
Gilmartin, Geoffrey S.;Tamisier, Renaud;Weiss, J. Woodrow
通讯作者：
Weiss, J. Woodrow