Female Fertility Has a Negative Relationship With Longevity in Chinese Oldest-Old Population: A Cross-Sectional Study.
Female Fertility Has a Negative Relationship With Longevity in Chinese Oldest-Old Population: A Cross-Sectional Study.
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中国高龄人群女性生育力与寿命呈负相关：一项横断面研究
DOI：
10.3389/fendo.2020.616207
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发表时间：
2020
影响因子：
5.2
通讯作者：
Yao Y
中科院分区：
文献类型：
--
作者：
Zhu Q;Fu S;Zhang Q;Tian J;Zhao Y;Yao Y
背景尽管在这一领域的研究工作已经进行了世纪，但女性生育能力和寿命之间的关系尚不清楚。本研究旨在探讨中国高龄老人的这种关系。方法采用中国海南省百岁老人队列研究方法，在海南省18个市县进行调查。共有1，226名女性，包括758名百岁女性和468名80-99岁女性，入组本研究。采用标准化的方案，由训练有素的研究小组通过家访进行面对面访谈和血液分析。结果与80-99岁妇女相比，百岁妇女的生育子女数（NOC）显著减少，初孕年龄（伊卡）和末次生育年龄（LCA）显著增加（均P < 0.05）。多因素Logistic回归分析显示，以百岁老人为参照，NOC和睾酮（T）水平与80-99岁妇女呈正相关（均P < 0.05）。伊卡、LCA和雌二醇（E2）水平与80-99岁的女性呈负相关，当百岁女性被视为参考时（所有p < 0.05）。结论中国百岁老人生育率与寿命呈负相关，且生育率与寿命呈负相关。血清E2水平与长寿呈正相关，血清T水平与长寿呈负相关。少生晚育可能是长寿的一个重要因素，减少和推迟生育可能促进成功老龄化。
Background Despite research efforts in this field for more than a century, the relationship between female fertility and longevity is unclear. This study was designed to investigate this relationship in Chinese oldest-old population. Methods The China Hainan Centenarian Cohort Study was performed in 18 cities and counties of Hainan. A total of 1,226 females, including 758 centenarian women and 468 women aged 80–99 years, were enrolled in this study. Using a standardized protocol, in-person interviews and blood analyses were conducted by a well-trained research team through home visits. Results Centenarian women had significantly lower number of children (NOC) and higher initial childbearing age (ICA) and last childbearing age (LCA) than women aged 80–99 years (p < 0.05 for all). Multivariate logistic regression analysis showed that NOC and testosterone (T) levels were positively associated with women aged 80–99 years, when centenarian women was considered as reference (p < 0.05 for all). ICA, LCA, and estradiol (E2) levels were negatively associated with women aged 80–99 years, when centenarian women was considered as reference (p < 0.05 for all). Conclusions The centenarians had crucial characteristics of less and delayed childbearing, indicating a negative relationship between female fertility and longevity in Chinese oldest-old population. Serum E2 levels were positively associated and serum T levels were negatively associated with longevity. The less and late childbearing might be a significant factor of longevity, and successful aging might be promoted by reducing and delaying female childbearing.
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影响因子：
2.4
作者：
Dribe, M
通讯作者：
Dribe, M
影响因子：
6.7
作者：
Gielchinsky, Yuval;Bogoch, Yoel;Laufer, Neri
通讯作者：
Laufer, Neri
DOI：
10.1093/gerona/glq163
发表时间：
2011-01-01
影响因子：
5.1
作者：
Goegele, Martin;Pattaro, Cristian;Wjst, Matthias
通讯作者：
Wjst, Matthias
影响因子：
4.6
作者：
Gordon, E. H.;Peel, N. M.;Hubbard, R. E.
通讯作者：
Hubbard, R. E.
影响因子：
15.8
作者：
Holt-Lunstad J;Smith TB;Layton JB
通讯作者：
Layton JB