Effects of zinc and vitamin A supplementation on prognostic markers and treatment outcomes of adults with pulmonary tuberculosis: a systematic review and meta-analysis.
Effects of zinc and vitamin A supplementation on prognostic markers and treatment outcomes of adults with pulmonary tuberculosis: a systematic review and meta-analysis.
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DOI：
10.1136/bmjgh-2022-008625
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发表时间：
2022-09
影响因子：
8.1
通讯作者：
Gray, Darren
中科院分区：
文献类型：
--
作者：
Wagnew, Fasil;Alene, Kefyalew Addis;Eshetie, Setegn;Wingfield, Tom;Kelly, Matthew;Gray, Darren
营养不良是结核病(TB)的主要风险因素，据估计，全球每年有190万 结核病病例是由营养不良造成的。补充微量营养素对结核病治疗结果及其预后标记物(痰转阴、血清锌、视黄醇和血红蛋白水平)的有效性一直知之甚少。本研究旨在确定补充锌和维生素A对成人肺结核患者的预后标志物和结核病治疗结果的影响。在PubMed、Embase和Scope数据库中对随机对照试验(RCT)进行系统的文献搜索。使用随机效应模型进行Meta分析，分别估计二分和连续结果的风险比(RR)和平均差值(MD)，可信区间为95%。我们的搜索发现了2195条记录。其中，包括1375名参与者的9个随机对照试验被纳入最终分析。在成人肺结核患者中，补充锌(RR：0.94，95% CI：0.86~1.0 3)、维生素A(RR：0.90，95% CI：0.80~1.0 1)和联合补充锌和维生素A(RR：0.98，95% CI：0.89~1.0 8)与结核病治疗成功无关。2个月时(RR：1.16，95% CI：1.03~1.32)、2个月时血清锌水平(MD：0.86 μ/L，95% CI：0.14~1.5 7)、2个月时(MD：0.06 μ/L，95%CI：0.04~0.08)和6个月时(MD：0.12 μ/L，6个月时血清血红蛋白水平(MD：0.29 μg/dL，95% CI：0.08~0.51)。成人肺结核患者在治疗期间补充锌和维生素A可能会增加早期痰涂片转阴率、血清锌、视黄醇和血红蛋白水平。然而，锌、维生素A或两者的使用与结核病治疗的成功无关。CRD42021248548。
Undernutrition is a major risk factor for tuberculosis (TB), which is estimated to be responsible for 1.9 million TB cases per year globally. The effectiveness of micronutrient supplementation on TB treatment outcomes and its prognostic markers (sputum conversion, serum zinc, retinol and haemoglobin levels) has been poorly understood. This study aimed to determine the effect of zinc and vitamin A supplementation on prognostic markers and TB treatment outcomes among adults with sputum-positive pulmonary TB. A systematic literature search for randomised controlled trials (RCTs) was performed in PubMed, Embase and Scopus databases. Meta-analysis with a random effect model was performed to estimate risk ratio (RR) and mean difference (MD), with a 95% CI, for dichotomous and continuous outcomes, respectively. Our search identified 2195 records. Of these, nine RCTs consisting of 1375 participants were included in the final analyses. Among adults with pulmonary TB, zinc (RR: 0.94, 95% CI: 0.86 to 1.03), vitamin A (RR: 0.90, 95% CI: 0.80 to 1.01) and combined zinc and vitamin A (RR: 0.98, 95% CI: 0.89 to 1.08) supplementation were not significantly associated with TB treatment success. Combined zinc and vitamin A supplementation was significantly associated with increased sputum smear conversion at 2 months (RR: 1.16, 95% CI: 1.03 to 1.32), serum zinc levels at 2 months (MD: 0.86 μmol/L, 95% CI: 0.14 to 1.57), serum retinol levels at 2 months (MD: 0.06 μmol/L, 95% CI: 0.04 to 0.08) and 6 months (MD: 0.12 μmol/L, 95% CI: 0.10 to 0.14) and serum haemoglobin level at 6 months (MD: 0.29 μg/dL, 95% CI: 0.08 to 0.51), among adults with pulmonary TB. Providing zinc and vitamin A supplementation to adults with sputum-positive pulmonary TB during treatment may increase early sputum smear conversion, serum zinc, retinol and haemoglobin levels. However, the use of zinc, vitamin A or both was not associated with TB treatment success. CRD42021248548.
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影响因子：
--
作者：
CHANDRA, RK
通讯作者：
CHANDRA, RK
DOI：
10.1590/s0036-36342010000300001
发表时间：
2010-06-01
期刊：
Salud Pública de México
影响因子：
--
作者：
Armijos, Rodrigo X;Weigel, M Margaret;Campos, Armando
通讯作者：
Campos, Armando
DOI：
10.13040/ijpsr.0975-8232.4(9).3426-31
发表时间：
2013-09-01
期刊：
INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH
影响因子：
--
作者：
Ginawi, Ibrahim A. M.;Ahmed, Mohammed Q.;Al-Hazimi, Awdah M.
通讯作者：
Al-Hazimi, Awdah M.
影响因子：
30.3
作者：
Botella H;Peyron P;Levillain F;Poincloux R;Poquet Y;Brandli I;Wang C;Tailleux L;Tilleul S;Charrière GM;Waddell SJ;Foti M;Lugo-Villarino G;Gao Q;Maridonneau-Parini I;Butcher PD;Castagnoli PR;Gicquel B;de Chastellier C;Neyrolles O
通讯作者：
Neyrolles O
影响因子：
7.1
作者：
Feillet-Coudray, C;Meunier, N;Coudray, C
通讯作者：
Coudray, C