Long-Term Sodium Ferulate Supplementation Scavenges Oxygen Radicals and Reverses Liver Damage Induced by Iron Overloading.
Long-Term Sodium Ferulate Supplementation Scavenges Oxygen Radicals and Reverses Liver Damage Induced by Iron Overloading.
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长期补充阿魏酸钠可清除氧自由基并逆转铁超载引起的肝损伤
DOI：
10.3390/molecules21091219
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发表时间：
2016-09-16
期刊：
影响因子：
--
通讯作者：
He M
中科院分区：
文献类型：
--
作者：
Qiao Y;He H;Zhang Z;Liao Z;Yin D;Liu D;Yi B;He M
阿魏酸是一种多酚类化合物，存在于各种水果和麦麸中。阿魏酸钠（SF）作为活性成分的盐，具有很强的自由基清除活性，能有效地清除ROS。在这项研究中，我们研究了SF对铁超载小鼠的影响，并与标准抗氧化剂牛磺酸（TAU）进行了比较。我们通过检测大鼠腹腔注射10%葡萄糖后肝体比（%）、转氨酶和肝细胞凋亡来确定SF对肝损伤的保护作用。此外，抗氧化酶活性，ROS的形成，线粒体肿胀，线粒体膜电位（MMP）都进行了评估，以阐明与氧化应激的SF保护作用的机制。SF治疗15周后，我们发现与TAU相比，铁注射后肝体重比显著降低，转氨酶和肝细胞凋亡升高。SF和TAU均能显著减轻小鼠铁超载引起的肝功能损害，但对铁摄取均无显著影响。此外，SF或TAU在铁超载小鼠中的治疗减弱了氧化应激，与氧化酶活性升高相关，降低了ROS的产生，防止了线粒体肿胀和MMP的消散，然后抑制了肝细胞凋亡。总之，目前的研究表明，与标准ROS清除剂（TAU）相比，SF减轻了与铁过载条件相关的氧化应激和肝损伤，并可能鼓励食品和饮料作为健康和可持续成分的更高消费和利用。
Ferulic acid is a polyphenolic compound contained in various types of fruits and wheat bran. As a salt of the active ingredient, sodium ferulate (SF) has potent free radical scavenging activity and can effectively scavenge ROS. In this study, we examined the effect of SF on iron-overloaded mice in comparison to a standard antioxidant, taurine (TAU). We determined the protective role of SF against liver injury by examining liver-to-body ratio (%), transaminase and hepatocyte apoptosis in rats supplied with 10% dextrose intraperitoneal injection. In addition, antioxidative enzymes activities, ROS formation, mitochondrial swelling, and mitochondrial membrane potential (MMP) were all evaluated to clarify the mechanism of protective effect of SF associated with oxidative stress. After 15 weeks of SF treatment, we found a significant reduction in liver-to-body weight radio and elevation in both transaminase and hepatocyte apoptosis associated with iron-injected to levels comparable to those achieved with TAU. Both SF and TAU significantly attenuated the impaired liver function associated with iron-overloaded in mice, whereas neither showed any significant effect on the iron uptake. Furthermore, treatment with either SF or TAU in iron-overloaded mice attenuated oxidative stress, associated with elevated oxidant enzymes activities, decreased ROS production, prevented mitochondrial swelling and dissipation of MMP and then inhibited hepatic apoptosis. Taken together, the current study shows that, SF alleviated oxidative stress and liver damage associated with iron-overload conditions compared to the standard ROS scavenger (TAU), and potentially could encourage higher consumption and utilization as healthy and sustainable ingredients by the food and drink.
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影响因子：
0.7
作者：
Aikemu A;Yusup A;Umar A;Berké B;Moore N;Upur H
通讯作者：
Upur H
影响因子：
8.8
作者：
Khallouki, Farid;Haubner, Roswitha;Owen, Robert W.
通讯作者：
Owen, Robert W.
DOI：
10.3390/molecules201119725
发表时间：
2015-11-23
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Kontoghiorghe CN;Kolnagou A;Kontoghiorghes GJ
通讯作者：
Kontoghiorghes GJ
DOI：
10.5493/wjem.v5.i4.218
发表时间：
2015-11-20
期刊：
World journal of experimental medicine
影响因子：
--
作者：
Lubrano, Valter;Balzan, Silvana
通讯作者：
Balzan, Silvana
影响因子：
3.6
作者：
Lenzi, Juliana;Rodrigues, Andre Felipe;Bertarello Zeni, Ana Lucia
通讯作者：
Bertarello Zeni, Ana Lucia