Application of Lactobaillus salivarius WB21 to the Oral Care of Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Crossover Comparative Study.
Application of Lactobaillus salivarius WB21 to the Oral Care of Healthy Older Adults: A Randomized, Double-Blind, Placebo-Controlled Crossover Comparative Study.
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DOI：
10.3390/life12091422
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发表时间：
2022-09-13
期刊：
影响因子：
3.2
通讯作者：
Hirofuji, Takao
中科院分区：
文献类型：
--
作者：
Kijima, Satoko;Suzuki, Nao;Hanioka, Takashi;Yoneda, Masahiro;Tanabe, Kazunari;Hirofuji, Takao
目的：在健康老年人群中进行了一项随机、双盲、安慰剂对照的交叉比较研究，以评估唾液乳杆菌WB 21（WB 21）摄入对口腔自我护理的有用性。方法：将33名健康老年人随机分为A、B组。A组在前两个月服用WB 21片剂，在随后的两个月服用安慰剂片剂。B组在前两个月服用安慰剂片剂，在随后的两个月服用WB 21片剂。在摄入前后，共进行了四次口腔检查、口腔气味试验和唾液收集。此外，健康状况是从研究中期的问卷调查中获得的。结果：A组2人、B组1人退出研究。因此，A组15人和B组15人被纳入分析。WB 21摄入两个月后，唾液分泌伊加显著增加（p = 0.047），舌苔评分显著降低（p = 0.013）。菌斑指数、探诊出血和口腔气味水平（H2S和CH 3SH浓度）没有变化。在6个月的研究期间，没有观察到龋齿、牙周炎恶化或口腔健康或全身主观症状的变化。结论：持续摄入含WB 21的片剂可以促进健康老年人的牙齿和口腔的自我护理。试验注册：R 000028335（UMIN-CTR）。
Objective: A randomized, double-blind, placebo-controlled crossover comparative study was conducted in a healthy older population to assess the usefulness of Lactobacillus salivarius WB21 (WB21) ingestion for oral self-care. Methods: The study population included 33 healthy older individuals who were randomly divided into two groups (A and B). Group A consumed WB21 tablets during the first two months and placebo tablets during the following two months. Group B consumed placebo tablets during the first two months and WB21 tablets during the following two months. Before and after ingestion, oral examination, mouth odor test, and saliva collection were performed a total of four times. In addition, health conditions were obtained from a questionnaire survey at the study’s midpoint. Results: Two people in group A and one person in group B dropped out of the study. Thus, 15 people in group A and 15 people in group B were included in the analysis. Over two months of WB21 ingestion, salivary secretory IgA increased significantly (p = 0.047) and tongue coating score decreased significantly (p = 0.013). The plaque index, bleeding on probing, and mouth odor levels (H2S and CH3SH concentrations) did not change. During the 6-month study period, no caries, deterioration of periodontitis, or changes in oral health or systemic subjective symptoms were observed. Conclusion: Continuous ingestion of WB21-containing tablets may promote self-care of the teeth and mouths of healthy older adults. Trial registration: R000028335 (UMIN-CTR).
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影响因子：
2.7
作者：
Chiniforush, Nasim;Pourhajibagher, Maryam;Bordea, Ioana Roxana
通讯作者：
Bordea, Ioana Roxana
影响因子：
7.6
作者：
Kraft-Bodi, E.;Jorgensen, M. R.;Twetman, S.
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Twetman, S.
影响因子：
5.4
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Braathen, G.;Ingildsen, V.;Jorgensen, M. R.
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Jorgensen, M. R.
影响因子：
5.4
作者：
Xiao, L.;Gong, C.;Ben, X.
通讯作者：
Ben, X.
影响因子：
23.4
作者：
ASO, Y;AKAZA, H;NAITO, S
通讯作者：
NAITO, S