Association of HLA-DP/DQ and STAT4 polymorphisms with HBV infection outcomes and a mini meta-analysis.
Association of HLA-DP/DQ and STAT4 polymorphisms with HBV infection outcomes and a mini meta-analysis.
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HLA-DP/DQ和STAT4多态性与HBV感染结果和小型荟萃分析的关联。
DOI：
10.1371/journal.pone.0111677
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Liao Y;Cai B;Li Y;Chen J;Tao C;Huang H;Wang L
虽然HLA-DP/DQ被认为与HBV易感性和HBV自然清除有关，但其在肝细胞癌（HCC）发生发展中的作用尚不清楚。STAT 4在HBV易感性和清除以及HCC发展中的作用仍存在争议。因此，我们进行了这项研究，旨在澄清这些模糊的关系。本研究共招募了1312名中国汉族受试者，包括健康对照、HBV携带者和HCC患者。荟萃分析包括3467例HCC患者和5821例HBV携带者，以评估与HCC发展的相关性。与以往研究一致，HLA-DP/DQ与HBV易感性和HBV自然清除相关（p<0.05）。然而，实验显示HLA-DP rs3077、rs 9277535和rs7453920与HCC的发展无关（显性模型，rs3077，OR = 0.86，95%CI = 0.62-1.18; rs 9277535，OR = 0.94，95%CI = 0.68-1.30; rs7453920，OR = 0.75，95%CI = 0.44-1.27）。 荟萃分析再次证实了这一结论（等位基因模型，rs3077，OR = 0.94，95%CI = 0.87-1.02; rs 9277535，OR = 1.04，95%CI = 0.97-1.11; rs7453920，OR = 0.89，95%CI = 0.76-1.02）。 STAT 4 rs7574865与HBV易感性（OR = 0.91，95%CI = 0.66-1.26）和HBV自然清除率（OR = 1.13，95%CI = 0.86-1.49）无显著相关性。 此外，目前的数据未能获得rs7574865与HCC发展的正相关性（实验，OR = 0.86，95%CI = 0.62-1.19;荟萃分析，OR = 0.87，95%CI = 0.74-1.03），这可能是由于样本量小。 HLA-DP/DQ多态性（rs3077、rs 9277535、rs7453920）与HCC的发生无关，但与HBV易感性和HBV自然清除相关。STAT 4 rs7574865似乎与HBV易感性或自然清除无关。目前，它在肝癌发生发展中的作用还不明确。
Though HLA-DP/DQ is regarded to associate with HBV susceptibility and HBV natural clearance, its role in hepatocellular carcinoma (HCC) development is obscure. And the role of STAT4 in HBV susceptibility and clearance as well as HCC development is still contentious. Therefore, we conducted this study, aiming to clarify these obscure relationships. We recruited 1312 Chinese Han subjects including healthy controls, HBV carriers and HCC patients in the experiment stage. The meta-analysis included 3467 HCC patients and 5821 HBV carriers to appraise the association with HCC development. Consistent with previous studies, HLA-DP/DQ associated with HBV susceptibility and HBV natural clearance (p<0.05). However, the experiment showed that HLA-DP rs3077, rs9277535 and rs7453920 did not associate with HCC development (dominant model, rs3077, OR = 0.86, 95%CI = 0.62–1.18; rs9277535, OR = 0.94, 95%CI = 0.68–1.30; rs7453920, OR = 0.75, 95%CI = 0.44–1.27). Meta-analysis again consolidated this conclusion (allele model, rs3077, OR = 0.94, 95%CI = 0.87–1.02; rs9277535, OR = 1.04, 95%CI = 0.97–1.11; rs7453920, OR = 0.89, 95%CI = 0.76–1.02). As for STAT4 rs7574865, we did not find any significant association with HBV susceptibility (OR = 0.91, 95%CI = 0.66–1.26) or HBV natural clearance (OR = 1.13, 95%CI = 0.86–1.49). Moreover, current data failed to acquire positive connection of rs7574865 with HCC development (experiment, OR = 0.86, 95%CI = 0.62–1.19; meta-analysis, OR = 0.87, 95%CI = 0.74–1.03), which may be due to the small sample size. HLA-DP/DQ polymorphisms (rs3077, rs9277535, rs7453920) did not associate with HCC development, but did correlate with HBV susceptibility and HBV natural clearance. STAT4 rs7574865 seemed not to correlate with HBV susceptibility or natural clearance. And it seemed rather ambiguous in its role on HCC development at present.
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影响因子：
44.1
作者：
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影响因子：
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作者：
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