Relationship of amyloid beta and neurofibrillary tau deposition in Neurodegeneration in Aging Down Syndrome (NiAD) study at baseline.
Relationship of amyloid beta and neurofibrillary tau deposition in Neurodegeneration in Aging Down Syndrome (NiAD) study at baseline.
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DOI：
10.1002/trc2.12096
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Cohen AD
中科院分区：
文献类型：
--
作者：
Tudorascu DL;Laymon CM;Zammit M;Minhas DS;Anderson SJ;Ellison PA;Zaman S;Ances BM;Sabbagh M;Johnson SC;Mathis CA;Klunk WE;Handen BL;Christian BT;Cohen AD
患有唐氏综合症（DS）的成年人显示阿尔茨海默病（AD）病理的风险很高，部分原因是编码淀粉样前体蛋白的21号染色体的三倍复制。患有退行性痴呆的成年人在30多岁时普遍受到阿尔茨海默病的影响，在60多岁时有70%到80%的几率患上临床痴呆。我们之前的研究评估了淀粉样蛋白β (Aβ)积累在DS中的纵向变化。本研究的目的是使用[18F]AV - 1451正电子发射断层扫描（PET）在DS中评估脑tau的存在，并使用匹兹堡化合物B (PiB) - PET评估脑tau病理与Aβ的关系。队列研究多中心研究参与者包括从社区招募的DS患者和兄弟姐妹对照；排除标准包括磁共振成像（MRI）禁忌症和/或认知功能受损的医学或精神状况。PET脑扫描评估Aβ ([11C]PiB)和tau （[18F]AV - 1451）负荷。使用多元线性回归模型（根据实际年龄、性别和表演场地进行调整）来检查区域[18F]AV‐1451标准摄取值比（SUVR）（基于与Braak阶段1—6相关的区域）和全球[11C]PiB SUVR（作为连续变量和二分类变量）之间的关系。156名参与者（平均年龄= 39.05，SD(8.4)）被检查。这些结果揭示了DS体内a β与tau病理之间的显著关系。作为一个二分类变量，[18F] PiB（+）参与者的每个Braak区域的AV‐1451保留率更高。我们还发现，基于我们的统计模型，从Braak 3感兴趣区域（ROI）开始，[18F]AV‐1451 SUVR沉积加速，[11C]PiB SUVR增加。
Adults with Down syndrome (DS) are at high‐risk of revealing Alzheimer's disease (AD) pathology, in part due to the triplication of chromosome 21 encoding the amyloid precursor protein. Adults with DS are uniformly affected by AD pathology by their 30′s and have a 70% to 80% chance of clinical dementia by their 60′s. Our previous studies have assessed longitudinal changes in amyloid beta (Aβ) accumulation in DS. The goal of the present study was to assess the presence of brain tau using [18F]AV‐1451 positron emission tomography (PET) in DS and to assess the relationship of brain tau pathology to Aβ using Pittsburgh Compound B (PiB)‐PET. Cohort study Multi‐center study Participants consisted of a sample of individuals with DS and sibling controls recruited from the community; exclusion criteria included contraindications for magnetic resonance imaging (MRI) and/or a medical or psychiatric condition that impaired cognitive functioning. PET brain scans to assess Aβ ([11C]PiB) and tau ([18F]AV‐1451) burden. Multiple linear regression models (adjusted for chronological age, sex and performance site) were used to examine associations between regional [18F]AV‐1451 standard uptake value ratio (SUVR) (based on regions associated with Braak stages 1‐6) and global [11C]PiB SUVR (as both a continuous and dichotomous variable). A cohort of 156 participants (mean age = 39.05, SD(8.4)) were examined. These results revealed a significant relationship between in vivo Aβ and tau pathology in DS. As a dichotomous variable, [18F]AV‐1451 retention was higher in each Braak region in PiB(+) participants. We also found, based on our statistical models, starting with the Braak 3 region of interest (ROI), an acceleration of [18F]AV‐1451 SUVR deposition with [11C]PiB SUVR increases.
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影响因子：
11.2
作者：
Klunk, WE;Engler, H;Långström, B
通讯作者：
Långström, B
影响因子：
4
作者：
Chien, David T.;Bahri, Shadfar;Kolb, Hartmuth C.
通讯作者：
Kolb, Hartmuth C.
影响因子：
5.7
作者：
Tziortzi, Andri C.;Searle, Graham E.;Gunn, Roger N.
通讯作者：
Gunn, Roger N.
影响因子：
5.7
作者：
Cohen AD;Mowrey W;Weissfeld LA;Aizenstein HJ;McDade E;Mountz JM;Nebes RD;Saxton JA;Snitz B;Dekosky S;Williamson J;Lopez OL;Price JC;Mathis CA;Klunk WE
通讯作者：
Klunk WE
影响因子：
5.7
作者：
Mishra S;Gordon BA;Su Y;Christensen J;Friedrichsen K;Jackson K;Hornbeck R;Balota DA;Cairns NJ;Morris JC;Ances BM;Benzinger TLS
通讯作者：
Benzinger TLS