In search of a recognition memory engram.
In search of a recognition memory engram.
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DOI：
10.1016/j.neubiorev.2014.09.016
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发表时间：
2015-03
影响因子：
8.2
通讯作者：
Banks, P. J.
中科院分区：
文献类型：
--
作者：
Brown, M. W.;Banks, P. J.
本文综述了嗅周皮层在熟悉性辨别中的作用。行为，药理学和电生理学的证据被认为是。大脑皮层对于记忆的获取、提取和存储至关重要。证据表明，嗅周突触减弱是至关重要的。大量来自人类和动物研究的数据表明，再认记忆至少涉及两个可分离的过程：熟悉性辨别和回忆。个体视觉刺激的熟悉性辨别似乎受到以颞叶的嗅周皮层为中心的系统的影响。在嗅周皮层中编码先前发生的基本变化是当刺激重复时神经元反应的减少。神经网络模型表明，基于这种响应性变化的系统在信息论方面可能是非常有效的。一个审查的结果表明，嗅周皮层作为一个存储站点的识别记忆的对象，这种存储依赖于过程中产生的突触弱化。
The role of the perirhinal cortex in familiarity discrimination is reviewed. Behavioural, pharmacological and electrophysiological evidence is considered. The cortex is found to be essential for memory acquisition, retrieval and storage. The evidence indicates that perirhinal synaptic weakening is critically involved. A large body of data from human and animal studies using psychological, recording, imaging, and lesion techniques indicates that recognition memory involves at least two separable processes: familiarity discrimination and recollection. Familiarity discrimination for individual visual stimuli seems to be effected by a system centred on the perirhinal cortex of the temporal lobe. The fundamental change that encodes prior occurrence within the perirhinal cortex is a reduction in the responses of neurones when a stimulus is repeated. Neuronal network modelling indicates that a system based on such a change in responsiveness is potentially highly efficient in information theoretic terms. A review is given of findings indicating that perirhinal cortex acts as a storage site for recognition memory of objects and that such storage depends upon processes producing synaptic weakening.
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影响因子：
56.9
作者：
BATESON, PPG;ROSE, SPR;HORN, G
通讯作者：
HORN, G
影响因子：
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作者：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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