Immunological regulation of neurogenic niches in the adult brain.
Immunological regulation of neurogenic niches in the adult brain.
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DOI：
10.1016/j.neuroscience.2012.08.053
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发表时间：
2012-12-13
期刊：
影响因子：
3.3
通讯作者：
Garcia-Verdugo, J. M.
中科院分区：
文献类型：
--
作者：
Gonzalez-Perez, O.;Gutierrez-Fernandez, F.;Lopez-Virgen, V.;Collas-Aguilar, J.;Quinones-Hinojosa, A.;Garcia-Verdugo, J. M.
在哺乳动物中，神经发生和少突胶质发生是终生发生在成年大脑中的生发过程。脑室下区(SVZ)和颗粒下区(SGZ)是成人脑内主要的神经发生区。其中，星形胶质细胞亚群充当神经干细胞。越来越多的证据表明，促炎和其他免疫介质是进入SVZ和SGZ的神经前体的重要调节因子。有许多炎性细胞因子调节神经干细胞的功能。研究最多的有：白介素1、白介素6、肿瘤坏死因子-α、胰岛素样生长因子-1、生长调节癌基因-α、白血病抑制因子、心肌营养素-1、睫状神经营养因子、干扰素-γ、单核细胞趋化蛋白-1和巨噬细胞炎性蛋白-1。这种过多的免疫介质可以控制神经干细胞及其后代的迁移、增殖、静止、细胞命运的选择和存活。因此，全身性或局部性炎症过程是成人大脑中生发壁龛的重要调节因素。在这篇综述中，我们总结了在体外和体内条件下，促炎细胞因子参与成人神经干细胞调控的最新证据。此外，我们还描述了前炎性细胞因子在神经退行性疾病中的作用，以及神经前体细胞免疫调节的一些治疗方法。
In mammals, neurogenesis and oligodendrogenesis are germinal processes that occur in the adult brain throughout life. The subventricular (SVZ) and subgranular (SGZ) zones are the main neurogenic regions in adult brain. Therein, it resides a subpopulation of astrocytes that act as neural stem cells. Increasing evidence indicates that pro-inflammatory and other immunological mediators are important regulators of neural precursors into the SVZ and the SGZ. There are a number of inflammatory cytokines that regulate the function of neural stem cells. Some of the most studied include: interleukin-1, interleukin-6, tumor necrosis factor-alpha, insulin-like growth factor-1, growth-regulated oncogene-alpha, leukemia inhibitory factor, cardiotrophin-1, ciliary neurotrophic factor, interferon-gamma, monocyte chemotactic protein-1 and macrophage inflammatory protein-1alpha. This plethora of immunological mediators can control the migration, proliferation, quiescence, cell-fate choices and survival of neural stem cells and their progeny. Thus, systemic or local inflammatory processes represent important regulators of germinal niches in the adult brain. In this review, we summarized the current evidence regarding the effects of pro-inflammatory cytokines involved in the regulation of adult neural stem cells under in vitro and in vivo conditions. Additionally, we described the role of proinflammatory cytokines in neurodegenerative diseases and some therapeutical approaches for the immunomodulation of neural progenitor cells.
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影响因子：
4.8
作者：
Akiyama, S;Yonezawa, T;Kobayashi, T
通讯作者：
Kobayashi, T
影响因子：
9.3
作者：
Alboni S;Cervia D;Sugama S;Conti B
通讯作者：
Conti B
影响因子：
--
作者：
Bonfanti L
通讯作者：
Bonfanti L
DOI：
10.1073/pnas.2234031100
发表时间：
2003-11-11
影响因子：
11.1
作者：
Ekdahl, CT;Claasen, JH;Lindvall, O
通讯作者：
Lindvall, O
影响因子：
16.2
作者：
Aimone JB;Deng W;Gage FH
通讯作者：
Gage FH