Integrated micro/nanoengineered functional biomaterials for cell mechanics and mechanobiology: a materials perspective.
Integrated micro/nanoengineered functional biomaterials for cell mechanics and mechanobiology: a materials perspective.
复制标题
DOI：
10.1002/adma.201304431
复制
发表时间：
2014-03-12
影响因子：
29.4
通讯作者：
Fu, Jianping
中科院分区：
文献类型：
--
作者：
Shao, Yue;Fu, Jianping
过去二十年微纳米工程功能生物材料的快速发展使材料科学家和生物工程师能够精确控制体外细胞微环境的不同方面。遵循还原论的哲学，许多使用合成功能生物材料的研究揭示了个体细胞外生物物理和生化线索在调节细胞行为中的指导作用。近年来，用于研究复杂和突发生物现象的集成微/纳米工程功能生物材料的开发也迅速蓬勃发展，揭示了与人类生理和病理条件密切相关的适应性和集成细胞行为。我们致力于材料科学与工程、生物学和医学之间的交叉领域，目前正处于利用微/纳米工程功能生物材料进行基础生物学研究以及再生医学和药物筛选等临床和生物医学应用的伟大探索的开始。在这篇综述中，我们概述了最先进的微/纳米工程功能生物材料，这些材料可以精确控制细胞-微环境相互作用的各个方面，并强调它们作为机械敏感和响应性细胞行为和综合生物学研究的机械研究的良好控制平台。我们还讨论了最近令人兴奋的趋势，即微/纳米工程生物材料被集成到微型生物和仿生系统中，以对新兴和集成的细胞行为进行动态多参数微环境控制。讨论了集成微/纳米工程功能生物材料对未来再生医学、细胞生物学以及人类发育和疾病模型体外研究的影响。
The rapid development of micro/nanoengineered functional biomaterials in the last two decades has empowered materials scientists and bioengineers to precisely control different aspects of the in vitro cell microenvironment. Following a philosophy of reductionism, many studies using synthetic functional biomaterials have revealed instructive roles of individual extracellular biophysical and biochemical cues in regulating cellular behaviors. Development of integrated micro/nanoengineered functional biomaterials to study complex and emergent biological phenomena has also thrived rapidly in recent years, revealing adaptive and integrated cellular behaviors closely relevant to human physiological and pathological conditions. Working at the interface between materials science and engineering, biology, and medicine, we are now at the beginning of a great exploration using micro/nanoengineered functional biomaterials for both fundamental biology study and clinical and biomedical applications such as regenerative medicine and drug screening. In this review, we present an overview of state of the art micro/nanoengineered functional biomaterials that can control precisely individual aspects of cell-microenvironment interactions and highlight them as well-controlled platforms for mechanistic studies of mechano-sensitive and -responsive cellular behaviors and integrative biology research. We also discuss the recent exciting trend where micro/nanoengineered biomaterials are integrated into miniaturized biological and biomimetic systems for dynamic multiparametric microenvironmental control of emergent and integrated cellular behaviors. The impact of integrated micro/nanoengineered functional biomaterials for future in vitro studies of regenerative medicine, cell biology, as well as human development and disease models are discussed.
登录
查看更多内容
影响因子：
2.9
作者：
Arnold, M;Cavalcanti-Adam, EA;Spatz, JP
通讯作者：
Spatz, JP
影响因子：
14
作者：
Banerjee, Akhilesh;Arha, Manish;Choudhary, Soumitra;Ashton, Randolph S.;Bhatia, Surita R.;Schaffer, David V.;Kane, Ravi S.
通讯作者：
Kane, Ravi S.
影响因子：
21.3
作者：
Balaban, NQ;Schwarz, US;Geiger, B
通讯作者：
Geiger, B
影响因子：
7.8
作者：
Beningo, KA;Dembo, M;Wang, YL
通讯作者：
Wang, YL
影响因子：
6.1
作者：
Azioune, Ammar;Storch, Marko;Piel, Matthieu
通讯作者：
Piel, Matthieu