Clinical evaluation of the neurophysins as tumor markers in small cell lung cancer.
Clinical evaluation of the neurophysins as tumor markers in small cell lung cancer.
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神经生理素作为小细胞肺癌肿瘤标志物的临床评价。
DOI：
10.1007/978-3-642-82533-0_21
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Maurer,LH
中科院分区：
文献类型：
--
作者：
North,WG;Ware,J;Chahinian,AP;Perry,M;O'Donnell,J;Maurer,LH
小细胞<：肺腺癌（SCCL）经常与肽激素的异位产生有关，其中一些肽激素在患者中产生显著的临床和实验室异常。抗利尿激素（SIADH）的不适当产生和促肾上腺皮质激素（ACTH）的异位分泌的综合征已被充分描述，并发生在患有这种疾病的5%-10%的患者中（Kato等，1969;埃根等，197 4; Lokich 1982）。肽类激素（如降钙素、血管加压素、阿黑皮素原及其代谢产物（促肾上腺皮质激素、促脂素、B-内啡肽））、神经垂体后叶素和其他蛋白质（如癌胚抗原、神经元特异性烯醇化酶和肌酸激酶BB同工酶）的灵敏放射免疫测定法的发展已导致SCCL中这些物质的检测。在其他类型的肺癌中也检测到这些肽和蛋白质，但SCCL中的检测频率和定量水平都要高得多。对SCCL细胞系的研究有助于扩大在培养中可检测到的激素的列表。蛙皮素在大比例的小细胞培养系中检测到，可能发挥自分泌作用（Moody et al. 1981; Sorenson et al. 1982）。然而，蛙皮素的血清水平升高并不常见（Wood et al. 1982）。肿瘤产生激素的生物学意义仍然难以捉摸，但这些肽的检测为临床医生提供了一个机会，以评估它们作为可能的肿瘤标志物。作为肿瘤标志物，它们可以提供有关分期的信息，作为预后因素，并被证明在监测治疗效果方面很有用。免疫组织化学技术结合血浆水平的测量，可能有助于根据肿瘤产生肽激素的能力来定义新的病理分类。
Small cell<: arcinoma of the lung (SCCL) is frequently associated with the ectopic production of peptide hormones, some of which produce significant clinical and laboratory abnormalities in the patient. The syndromes of inappropriate production of antidiuretic hormone (SIADH) and the ectopic secretion of adrenocorticotropic hormone (ACTH) have been well described and occur in 5%-10% of patients suffering from this disease (Kato et al. 1969; Eagan et al. 197 4; Lokich 1982). The development of sensitive radioimmunoassays for peptide hormones such as calcitonin, vasopressin, pro-opiomelanocortin and its metabolites (ACTH, lipotropin, B-endorphin), for the neurophysins, and for other proteins, such as carcinoembryonic antigen, neuron-specific enolase, and the BB isoenzyme of creatine kinase, have led to the detection of these substances in SCCL. These peptides and proteins have also been detected in other types of lung cancer, but both the frequency of detection and the quantitative levels are much higher in SCCL. Studies of cell lines of SCCL have contributed to an expansion of the list of hormones detectable in culture. Bombesin is detected in a large percentage of small cell culture lines and may be functioning in an autocrine role (Moody et al. 1981; Sorenson et al. 1982). However, elevated serum levels of bombesin are infrequent (Wood et al. 1982). The biological significance of hormone production by tumors remains elusive, but the detection of these peptides offers the clinician an opportunity to evaluate them as possible tumor markers. As tumor markers they may provide information about staging, serve as prognostic factors, and prove to be useful in monitoring the effects of therapy. Immunohistochemical techniques when combined with measurement of plasma levels may help define new pathological classifications based on the capability of tumors to produce peptide hormones.
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肿瘤中存在神经素的证据会产生不适当的抗利尿综合征。
DOI：
10.1210/jcem-35-5-764
发表时间：
1972
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
B. Hamilton;G. V. Upton;Thomas T. Amatruda
通讯作者：
Thomas T. Amatruda
产生异位加压素的肺燕麦细胞癌中免疫反应性神经素的性质。
DOI：
10.1172/jci110267
发表时间：
1981
期刊：
The Journal of clinical investigation
影响因子：
--
作者：
T. Yamaji;M. Ishibashi;S. Katayamá
通讯作者：
S. Katayamá
肺癌中循环ACTH和相关肽。
影响因子：
8.8
作者：
Ratcliffe, J G;Podmore, J;Stack, B H;Spilg, W G;Gropp, C
通讯作者：
Gropp, C
人类两种神经生理素的生理控制。
影响因子：
5.8
作者：
A. G. Robinson;C. Haluszczak;J. Wilkins;A. Huellmantel;C. Watson
通讯作者：
C. Watson
人类神经素作为小细胞肺癌的潜在肿瘤标志物：特异性放射免疫测定的应用。
DOI：
10.1210/jcem-51-4-892
发表时间：
1980
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
North,WG;Maurer,LH;Valtin,H;O'Donnell,JF
通讯作者：
O'Donnell,JF