Parafoveal OCT Angiography Features in Diabetic Patients without Clinical Diabetic Retinopathy: A Qualitative and Quantitative Analysis.
Parafoveal OCT Angiography Features in Diabetic Patients without Clinical Diabetic Retinopathy: A Qualitative and Quantitative Analysis.
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DOI：
10.1155/2017/8676091
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发表时间：
2017
影响因子：
1.9
通讯作者：
Souied EH
中科院分区：
文献类型：
--
作者：
Goudot MM;Sikorav A;Semoun O;Miere A;Jung C;Courbebaisse B;Srour M;Freiha JG;Souied EH
评价OCT血管造影（OCTA）检测无糖尿病视网膜病变（DR）的糖尿病患者视网膜旁毛细血管临床下病变的能力。 这项前瞻性观察性横断面病例对照研究分析了以中央凹为中心的黄斑OCTA扫描（3 × 3 mm）的浅表和深部毛细血管丛（SCP和DCP）。我们比较了22例糖尿病患者（包括34只眼）的彩色眼底照片没有DR诊断，与22名年龄和性别匹配的非糖尿病对照组（包括40只眼）。定性分析涉及形态学缺血性毛细血管改变。定量分析测量了SCP和DCP之间的中心凹无血管区（FAZ）大小、血管旁毛细血管密度和FAZ扩大系数。 两组之间的定性和定量参数均无显著差异。在任何分析的图像中均未观察到微动脉瘤或静脉迂曲。在SCP上，糖尿病患者的平均FAZ面积为0.322 ± 0.125 mm2，对照组为0.285 ± 0.150 mm2，P = 0.31。在DCP上，病例组的平均FAZ面积为0.444 ± 0.153 mm2，对照组为0.398 ± 0.138 mm2，P = 0.20。 与非糖尿病对照组相比，OCTA未检测到无DR的糖尿病患者血管旁毛细血管的临床下定性或定量差异。
To evaluate the capacity of OCT angiography (OCTA) for detecting infraclinical lesions in parafoveal capillaries in diabetic patients without diabetic retinopathy (DR). This prospective observational cross-sectional case-control study analyzed the superficial and deep capillary plexuses (SCP and DCP) on macular OCTA scans (3 × 3 mm) centered on the fovea. We compared 22 diabetic patients (34 eyes included) without DR diagnosis on color fundus photographs, with 22 age- and gender-matched nondiabetic controls (40 eyes included). Qualitative analysis concerned morphological ischemic capillary alterations. Quantitative analysis measured foveal avascular zone (FAZ) size, parafoveal capillary density, and enlargement coefficient of FAZ between SCP and DCP. Neither the qualitative nor quantitative parameters were significantly different between both groups. No microaneurysms or venous tortuosity was observed in any of the analyzed images. On the SCP, the mean FAZ area was 0.322 ± 0.125 mm2 in diabetic patients and 0.285 ± 0.150 mm2 in controls, P = 0.31. On the DCP, the mean FAZ area was 0.444 ± 0.153 mm2 in cases and 0.398 ± 0.138 mm2 in controls, P = 0.20. OCTA did not detect infraclinical qualitative or quantitative differences in parafoveal capillaries of diabetic patients without DR in comparison with nondiabetic controls.
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影响因子：
3.8
作者：
Jia Y;Tan O;Tokayer J;Potsaid B;Wang Y;Liu JJ;Kraus MF;Subhash H;Fujimoto JG;Hornegger J;Huang D
通讯作者：
Huang D
影响因子：
13.7
作者：
Bresnick, GH;Mukamel, DB;Cole, DR
通讯作者：
Cole, DR
DOI：
10.1007/s00417-015-3143-7
发表时间：
2016-05-01
影响因子：
2.7
作者：
Di, Gong;Yu Weihong;Dong Fangtian
通讯作者：
Dong Fangtian
DOI：
10.1097/iae.0000000000000859
发表时间：
2015-11-01
影响因子：
3.3
作者：
Couturier, Aude;Mane, Valerie;Tadayoni, Ramin
通讯作者：
Tadayoni, Ramin
影响因子：
4.4
作者：
Dubis, Adam M.;Hansen, Benjamin R.;Carroll, Joseph
通讯作者：
Carroll, Joseph