Systemic inflammation is associated with differential neural reactivity and connectivity to affective images.
Systemic inflammation is associated with differential neural reactivity and connectivity to affective images.
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DOI：
10.1093/scan/nsaa065
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发表时间：
2020-11-10
影响因子：
4.2
通讯作者：
Muscatell KA
中科院分区：
文献类型：
--
作者：
Alvarez GM;Hackman DA;Miller AB;Muscatell KA
全身性炎症越来越被认为是健康和福祉的预测因素。此外，炎症已被证明会影响情感体验，并受情感体验的影响。虽然先前的工作已经证实了炎症和情感过程之间的关联，但很少有研究调查系统性低度炎症和情感反应之间联系的神经生物学相关性。因此，目前的研究检查是否全身性炎症的标志物（即白细胞介素-6，C-反应蛋白）与不同的模式的神经激活和连接在皮质边缘区响应情感图像。我们调查了这个问题的66名成年人（44名女性，M年龄= 54.98岁，范围= 35-76）从美国中年研究的样本。当观察阳性（与中性）图像时，较高水平的炎症与边缘区（即杏仁核、海马、前额叶、颞极）的较低活动相关。更高水平的炎症也与海马体和内侧前额叶皮层之间的更大连通性有关，以响应积极的图像。炎症标志物与激活或连接到阴性图像的显著差异无关。这些发现突出了健康神经科学方法的实用性，证明了炎症等生理过程与我们的大脑如何对情感信息做出反应有关。
Systemic inflammation is increasingly appreciated as a predictor of health and well-being. Further, inflammation has been shown to influence and be influenced by affective experiences. Although prior work has substantiated associations between inflammatory and affective processes, fewer studies have investigated the neurobiological correlates that underlie links between systemic, low-grade inflammation and affective reactivity. Thus, the current study examined whether markers of systemic inflammation (i.e. interleukin-6, C-reactive protein) are associated with differential patterns of neural activation and connectivity in corticolimbic regions in response to affective images. We investigated this question in a sample of 66 adults (44 women, M age = 54.98 years, range = 35–76) from the Midlife in the United States study. Higher levels of inflammation were associated with lower activity in limbic regions (i.e. amygdala, hippocampus, anterior insula, temporal pole) when viewing positive (vs neutral) images. Higher levels of inflammation were also associated with greater connectivity between the hippocampus and the medial prefrontal cortex in response to positive images. Inflammatory markers were not associated with significant differences in activation or connectivity to negative images. These findings highlight the utility of health neuroscience approaches in demonstrating that physiological processes such as inflammation are related to how our brains respond to affective information.
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影响因子：
8.2
作者：
Heller AS;van Reekum CM;Schaefer SM;Lapate RC;Radler BT;Ryff CD;Davidson RJ
通讯作者：
Davidson RJ
影响因子：
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Kubzansky, Laura D.
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Sturmberg, Joachim P.