Sustained striatal activity predicts eudaimonic well-being and cortisol output.

Sustained striatal activity predicts eudaimonic well-being and cortisol output.
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DOI:
10.1177/0956797613490744
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发表时间:
2013-11-01
影响因子:
8.2
通讯作者:
Davidson RJ
Davidson RJ
中科院分区:
心理学1区
文献类型:
--
作者:
Heller AS;van Reekum CM;Schaefer SM;Lapate RC;Radler BT;Ryff CD;Davidson RJ

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幸福感是一种目标感、意义感和对生活的参与感,它可以预防精神病理学,并预测身体健康,包括降低应激激素皮质醇的水平。虽然有人认为,参与奖励神经回路的能力可能会促进幸福感,并调解幸福感和健康之间的关系,但这一假设尚未得到验证。为了验证这一假设,我们让参与者在收集fMRI数据的同时观看积极、中性和消极的图像。在扫描过程中,纹状体和背外侧前额叶皮层对积极刺激持续活跃的个体报告说,他们的幸福感更高,皮质醇分泌量更低。这表明,持续参与的奖励电路在积极的事件作出反应的基础福祉和适应性调节下丘脑-垂体-肾上腺轴。
Eudaimonic well-being—a sense of purpose, meaning, and engagement with life—is protective against psychopathology and predicts physical health, including lower levels of the stress hormone cortisol. Although it has been suggested that the ability to engage the neural circuitry of reward may promote well-being and mediate the relationship between well-being and health, this hypothesis has remained untested. To test this hypothesis, we had participants view positive, neutral, and negative images while fMRI data were collected. Individuals with sustained activity in the striatum and dorsolateral prefrontal cortex to positive stimuli over the course of the scan session reported greater well-being and had lower cortisol output. This suggests that sustained engagement of reward circuitry in response to positive events underlies well-being and adaptive regulation of the hypothalamic-pituitary-adrenal axis.
在大鼠和人类中持续的恐惧:恐惧与焦虑中的杏仁核的作用。
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