Sustained striatal activity predicts eudaimonic well-being and cortisol output.
Sustained striatal activity predicts eudaimonic well-being and cortisol output.
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DOI:
10.1177/0956797613490744
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发表时间:
2013-11-01
影响因子:
8.2
通讯作者:
Davidson RJ
中科院分区:
文献类型:
--
作者:
Heller AS;van Reekum CM;Schaefer SM;Lapate RC;Radler BT;Ryff CD;Davidson RJ
Eudaimonic well-being—a sense of purpose, meaning, and engagement with life—is protective against psychopathology and predicts physical health, including lower levels of the stress hormone cortisol. Although it has been suggested that the ability to engage the neural circuitry of reward may promote well-being and mediate the relationship between well-being and health, this hypothesis has remained untested. To test this hypothesis, we had participants view positive, neutral, and negative images while fMRI data were collected. Individuals with sustained activity in the striatum and dorsolateral prefrontal cortex to positive stimuli over the course of the scan session reported greater well-being and had lower cortisol output. This suggests that sustained engagement of reward circuitry in response to positive events underlies well-being and adaptive regulation of the hypothalamic-pituitary-adrenal axis.
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DOI:
10.1038/npp.2009.109
发表时间:
2010-01
期刊:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子:
--
作者:
通讯作者:
--
DOI:
10.1176/appi.ajp.2012.12010014
发表时间:
2013-02
期刊:
The American journal of psychiatry
影响因子:
--
作者:
Heller AS;Johnstone T;Light SN;Peterson MJ;Kolden GG;Kalin NH;Davidson RJ
通讯作者:
Davidson RJ
影响因子:
4.8
作者:
Owen, AM;McMillan, KM;Bullmore, ET
通讯作者:
Bullmore, ET
影响因子:
3.7
作者:
Pruessner, JC;Kirschbaum, C;Hellhammer, DH
通讯作者:
Hellhammer, DH
DOI:
10.1073/pnas.0910651106
发表时间:
2009-12-29
影响因子:
11.1
作者:
Heller, Aaron S.;Johnstone, Tom;Davidson, Richard J.
通讯作者:
Davidson, Richard J.